Pediatrics, André Mignot Hospital, Versailles, France.
Department of General Pediatrics and Pediatric Infectious Diseases, Necker-Enfants Malades University Hospital, Paris, France; Université de Paris Cité, Paris, France.
Arch Pediatr. 2023 Jul;30(5):343-346. doi: 10.1016/j.arcped.2023.02.007. Epub 2023 Mar 27.
Lemierre syndrome is typically associated with ear, nose, and throat (ENT) infections caused by Fusobacterium necrophorum. Since 2002, cases of atypical Lemierre-like syndrome secondary to Staphylococcus aureus have been reported.
We report two pediatric cases of atypical Lemierre syndrome with a similar presentation: exophthalmia, absence of pharyngitis, metastatic lung infection, and intracranial venous sinus thrombosis. Both patients had a favorable outcome following treatment with antibiotics, anticoagulation, and corticosteroids.
Regular therapeutic monitoring of antibiotic levels helped to optimize antimicrobial treatment in both cases.
林氏综合征通常与由坏死梭杆菌引起的耳部、鼻部和喉部（ENT）感染有关。自 2002 年以来，已有报道称金黄色葡萄球菌引起的非典型林氏样综合征病例。
我们报告了两例儿科非典型林氏综合征病例，其表现相似：眼球突出、无咽炎、转移性肺部感染和颅内静脉窦血栓形成。两例患者均经抗生素、抗凝和皮质类固醇治疗后预后良好。
定期监测抗生素水平有助于优化两种情况下的抗菌治疗。
