Patankar Sangeeta R, Khetan Palak, Choudhari Sheetal K, Suryavanshi Harshal
Department of Oral Pathology and Microbiology, Yerala Medical Trust's Dental College and Hospital, Navi Mumbai 410210, Maharashtra, India.
Department of Oral and Maxillofacial Surgery, Yerala Medical Trust's Dental College and Hospital, Navi Mumbai 410210, Maharashtra, India.
World J Clin Oncol. 2019 Apr 24;10(4):192-200. doi: 10.5306/wjco.v10.i4.192.
Dentinogenic ghost cell tumor (DGCT) is an uncommon locally invasive odontogenic neoplasm. It is considered to be a solid variant of calcifying odontogenic cyst (COC). This tumor makes up for only 2%-14% of all COCs and less than 0.5% of all odontogenic tumors which owes to its rarity. The purpose of this paper was to describe a case of DGCT and the treatment adopted in our case, and to provide a review of this case in the indexed literature.
In this article, we discussed a case of 18 year old male who reported with a chief complaint of a recurrent swelling and dull aching pain in upper left back region of the jaw. Computed tomography scan was carried out which revealed hypodense lesion with a few hyperdense flecks within it suggesting the presence of calcification. On incisional biopsy, diagnosis of COC was given. After segmental resection of the lesion, histopathogically odontogenic epithelium was noted along with calcifications, ghost cells and dentinoid material. Special staining was done with van Gieson and it showed pink areas of dentinoid material and yellow colour represented ghost cells. Hence, amalgamation of careful clinical examination, use of advanced radiographic imaging and detailed histopathological examination confirmed the diagnosis of DGCT. The patient was followed up for one year and there was no recurrence of the lesion or signs of any residual tumor.
Radical treatment should be carried out along with mandatory long-term follow up in order to avoid recurrence in aggressive lesions.
牙源性影细胞肿瘤（DGCT）是一种罕见的局部侵袭性牙源性肿瘤。它被认为是牙源性钙化囊肿（COC）的实性变体。由于其罕见性，该肿瘤仅占所有COC的2%-14%，占所有牙源性肿瘤的比例不到0.5%。本文旨在描述一例DGCT病例及其治疗方法，并对相关文献进行综述。
在本文中，我们讨论了一例18岁男性患者，其主要症状为左上颌后区反复肿胀和钝痛。进行了计算机断层扫描，结果显示低密度病变，内有一些高密度斑点，提示存在钙化。切开活检诊断为COC。病变节段切除后，组织病理学检查发现牙源性上皮，伴有钙化、影细胞和类牙本质物质。采用范吉森特殊染色，结果显示类牙本质物质呈粉红色区域，黄色代表影细胞。因此，通过仔细的临床检查、先进的影像学检查和详细的组织病理学检查确诊为DGCT。对患者进行了一年的随访，病变无复发，也无任何残留肿瘤的迹象。
对于侵袭性病变，应进行根治性治疗并进行必要的长期随访，以避免复发。
