Ningbo Research Institute, Zhejiang University, Ningbo 315100, China.
State Key Laboratory of Modern Optical Instrumentation, College of Optical Science and Engineering, Zhejiang University, Hangzhou 310058, China.
Sensors (Basel). 2023 Mar 16;23(6):3198. doi: 10.3390/s23063198.
In this paper, an optical fiber Fabry-Pérot (FP) microfluidic sensor based on the capillary fiber (CF) and side illumination method is designed. The hybrid FP cavity (HFP) is naturally formed by the inner air hole and silica wall of CF which is side illuminated by another single mode fiber (SMF). The CF acts as a naturally microfluidic channel, which can be served as a potential microfluidic solution concentration sensor. Moreover, the FP cavity formed by silica wall is insensitive to ambient solution refractive index but sensitive to the temperature. Thus, the HFP sensor can simultaneously measure microfluidic refractive index (RI) and temperature by cross-sensitivity matrix method. Three sensors with different inner air hole diameters were selected to fabricate and characterize the sensing performance. The interference spectra corresponding to each cavity length can be separated from each amplitude peak in the FFT spectra with a proper bandpass filter. Experimental results indicate that the proposed sensor with excellent sensing performance of temperature compensation is low-cost and easy to build, which is suitable for in situ monitoring and high-precision sensing of drug concentration and the optical constants of micro-specimens in the biomedical and biochemical fields.
本文设计了一种基于毛细管光纤(CF)和侧面照明方法的光纤法布里-珀罗(FP)微流传感器。混合 FP 腔(HFP)由 CF 的内空气孔和二氧化硅壁自然形成,CF 由另一根单模光纤(SMF)侧面照明。CF 充当自然微流通道,可作为潜在的微流溶液浓度传感器。此外,由二氧化硅壁形成的 FP 腔对环境溶液折射率不敏感,但对温度敏感。因此,HFP 传感器可以通过交叉灵敏度矩阵方法同时测量微流体折射率(RI)和温度。选择了三个具有不同内空气孔直径的传感器进行制造和传感性能表征。可以用适当的带通滤波器从 FFT 光谱中的每个幅度峰值中分离出与每个腔长对应的干涉光谱。实验结果表明,具有出色温度补偿传感性能的新型传感器成本低廉且易于构建,适用于生物医学和生物化学领域中药物浓度和微样本光学常数的原位监测和高精度传感。