Poulsen Nautrup Barbara, Van Vlaenderen Ilse, Mellencamp Martha A
EAH-Consulting, 52064 Aachen, Germany.
CHESS, 2820 Bonheiden, Belgium.
Vaccines (Basel). 2023 Mar 3;11(3):584. doi: 10.3390/vaccines11030584.
This meta-analysis compared the efficacy of a chimeric vaccine against porcine circovirus type 2 (PCV2) containing the genotypes PCV2a+b (Fostera Gold PCV MH [FOS-G]), with commonly used vaccines being derived from genotype PCV2a, considering the following parameters: average daily gain (ADG), mortality and market classification as full value and cull. Data from seven hitherto unpublished comparative US field trials with FOS-G (two experimental challenges and five natural environmental studies) were provided by the manufacturer. A complementary literature review revealed a Korean study, which was considered separately in meta-analysis. Competitors were Circumvent PCV-M (CV) and Ingelvac Circoflex + Ingelvac Mycoflex (IC + IM) in the US, and Porcilis (POR) in Republic of Korea. Heterogeneity between experimental and environmental challenge studies in the US was not significant, justifying a combined analysis. Over the entire feeding period, ADG (11 comparisons), mortality (12 comparisons) and market classification were not significantly different between FOS-G and its competitor in the US setting. In the Korean study, however, ADG was higher in pigs vaccinated with FOS-G compared to POR, whereas mortality was not significantly different.
本荟萃分析比较了包含PCV2a + b基因型的嵌合猪圆环病毒2型（PCV2）疫苗（福斯特拉金猪圆环病毒MH [FOS-G]）与常用的源自PCV2a基因型疫苗的疗效，并考虑了以下参数：平均日增重（ADG）、死亡率以及市场分类（全价和淘汰）。制造商提供了来自美国七项迄今未发表的FOS-G比较性田间试验的数据（两项实验性攻毒试验和五项自然环境研究）。一项补充文献综述发现了一项韩国研究，该研究在荟萃分析中单独进行了考量。在美国，对照疫苗为PCV-M（CV）和英特威圆环疫苗+英特威支原体疫苗（IC + IM），在韩国为普乐维美（POR）。美国实验性攻毒试验和环境攻毒试验之间的异质性不显著，因此可以进行合并分析。在美国的环境中，在整个饲养期内，FOS-G与其对照疫苗之间的ADG（11项比较）、死亡率（12项比较）和市场分类均无显著差异。然而，在韩国的研究中，与POR相比，接种FOS-G的猪ADG更高，而死亡率无显著差异。
