Um Hyungmin, Yang Siyeon, Oh Taehwan, Park Keehwan, Cho Hyejean, Suh Jeongmin, Min Kyung-Duk, Chae Chanhee
Department of Veterinary Pathology, College of Veterinary Medicine, Seoul National University, Gwanak-ro 1, Gwanak-gu, Seoul 08826, Korea.
Institute of Health and Environment, Seoul National University, 1 Gwanak-ro, Gwanak-gu, Seoul 08826, Korea.
Vaccines (Basel). 2021 May 3;9(5):450. doi: 10.3390/vaccines9050450.
The present field trial compared two combined vaccines of porcine circovirus type 2 (PCV2) and , each administered in herd with subclinical PCV2d infection and enzootic pneumonia. One vaccine was a bivalent containing PCV2a and and the other was a trivalent vaccine containing PCV2a and 2b (PCV2a/b), and . The defining difference between these two vaccines was the inclusion or absence of PCV2b antigen. A total of 480, 21day-old pigs were randomly allocated to one of four treatment groups (120 pigs per group, male = 60 and female = 60). These groups included; one-dose trivalent-vaccinated, two-dose trivalent-vaccinated, one-dose bivalent-vaccinated, and unvaccinated. The one- and two-dose trivalent vaccinated pigs exhibited significantly better growth performance when compared with those vaccinated with the bivalent vaccine. The one- and two-dose trivalent vaccinated pigs also reduced the amount of PCV2d loads in the blood and feces, and resulted in a lower load in the larynx when compared with one-dose bivalent vaccinated pigs. Statistical differences were not observed between the one- and two-dose trivalent-vaccinated groups in terms of growth performance, serology, amount of PCV2d loads in the blood and feces, amount of load in larynx, and pathological lesions. The results of the present study will provide swine practitioners and producer with comparative clinical field data to select the proper vaccine and vaccination regiment for herds suffering from subclinical PCV2d infection and enzootic pneumonia.
本次田间试验比较了两种猪圆环病毒2型（PCV2）联合疫苗，每种疫苗均在患有亚临床PCV2d感染和地方性肺炎的猪群中进行接种。一种疫苗是包含PCV2a和[此处原文缺失一种成分名称]的二价疫苗，另一种是包含PCV2a和2b（PCV2a/b）以及[此处原文缺失一种成分名称]的三价疫苗。这两种疫苗的决定性差异在于是否包含PCV2b抗原。总共480头21日龄仔猪被随机分配到四个治疗组之一（每组120头猪，公猪60头，母猪60头）。这些组包括：单剂量三价疫苗接种组、双剂量三价疫苗接种组、单剂量二价疫苗接种组和未接种组。与接种二价疫苗的猪相比，单剂量和双剂量三价疫苗接种的猪生长性能显著更好。与单剂量二价疫苗接种的猪相比，单剂量和双剂量三价疫苗接种的猪还降低了血液和粪便中PCV2d的载量，并使喉部的[此处原文缺失一种病原体名称]载量降低。在生长性能、血清学、血液和粪便中PCV2d的载量、喉部[此处原文缺失一种病原体名称]的载量以及病理损伤方面，单剂量和双剂量三价疫苗接种组之间未观察到统计学差异。本研究结果将为猪从业者和生产者提供比较临床田间数据，以便为患有亚临床PCV2d感染和地方性肺炎的猪群选择合适的疫苗和接种方案。
