Al-Orini Dawood, Alshoshan Abdulrahman A, Almutiri Abdullah O, Almreef Abdulsalam A, Alrashidi Essa S, Almutiq Abdulrahman M, Noman Rehana, Al-Wutayd Osama
Primary Healthcare Center, Al Bedaya, Ministry of Health, Qassim 56361, Saudi Arabia.
Research Unit, Unaizah College of Medicine and Medical Sciences, Qassim University, Unaizah 56219, Saudi Arabia.
Vaccines (Basel). 2023 Mar 14;11(3):651. doi: 10.3390/vaccines11030651.
Vaccines have recently been made available free of charge by the Saudi Ministry of Health for people 50 years or older. Diabetes mellitus (DM) increases herpes zoster (HZ) susceptibility, severity, serious complications, and negative impacts on underlying DM conditions, which are highly prevalent in Saudi Arabia. This study aimed to assess the acceptability of the HZ vaccination and its predictors among patients with diabetes in the Qassim region of Saudi Arabia. A cross-sectional study of patients with diabetes from a primary healthcare center in the Qassim region was conducted. Information was obtained on sociodemographic characteristics, history of herpes zoster infection, knowing someone who had had herpes zoster, past vaccinations, and factors influencing their intention to receive the HZ vaccination through a self-administered online questionnaire. The median age (IQR) was 56 years (53-62). Overall, 25% (n = 104/410) of the participants reported their acceptability of the HZ vaccination, and the predictors were being male (AOR 2.01, 95% CI 1.01-4.00, = 0.047), believing the HZ vaccine was effective (AOR 3.94, 95% CI 2.25-6.90, < 0.001), and awareness that immunocompromised individuals are at a higher risk of contracting HZ (AOR 2.32, 95% CI 1.37-3.93, = 0.002). A total of 74.2% (n = 227/306) of the participants reported their acceptability of the HZ vaccination if advised by their physician, and the predictors were being male (AOR 2.37, 95% CI 1.18-4.79, = 0.016) and having a history of varicella vaccine uptake (AOR 4.50, 95% CI 1.02-19.86, = 0.047). One-quarter of the participants were ready to accept the HZ vaccine, but this proportion significantly increased when the patients were advised by their physicians. The uptake rate can be improved with the involvement of healthcare providers and focused awareness campaigns about the effectiveness of the vaccine.
沙特卫生部最近开始为50岁及以上的人群免费提供疫苗。糖尿病（DM）会增加带状疱疹（HZ）的易感性、严重程度、严重并发症以及对潜在糖尿病病情的负面影响，而糖尿病在沙特阿拉伯非常普遍。本研究旨在评估沙特卡西姆地区糖尿病患者对HZ疫苗的接受度及其预测因素。对卡西姆地区一家初级医疗中心的糖尿病患者进行了一项横断面研究。通过一份自行填写的在线问卷，收集了社会人口学特征、带状疱疹感染史、认识患带状疱疹的人、既往疫苗接种情况以及影响他们接种HZ疫苗意愿的因素等信息。年龄中位数（四分位间距）为56岁（53 - 62岁）。总体而言，25%（n = 104/410）的参与者表示接受HZ疫苗，预测因素为男性（比值比2.01，95%置信区间1.01 - 4.00，P = 0.047）、认为HZ疫苗有效（比值比3.94，95%置信区间2.25 - 6.90，P < 0.001）以及知晓免疫功能低下个体感染HZ的风险更高（比值比2.32，95%置信区间1.37 - 3.93，P = 0.002）。如果医生建议，共有74.2%（n = 227/306）的参与者表示接受HZ疫苗，预测因素为男性（比值比2.37，95%置信区间1.18 - 4.79，P = 0.016）和有接种水痘疫苗的历史（比值比4.50，95%置信区间1.02 - 19.86，P = 0.047）。四分之一的参与者愿意接受HZ疫苗，但当患者得到医生建议时，这一比例显著增加。通过医疗保健提供者的参与以及开展关于疫苗有效性的针对性宣传活动，可以提高疫苗接种率。
