严重急性呼吸综合征冠状病毒2减毒活疫苗的间接传播及其对群体免疫的贡献。

Indirect Dispersion of SARS-CoV-2 Live-Attenuated Vaccine and Its Contribution to Herd Immunity.

作者信息

Pacheco-García Ursino, Serafín-López Jeanet

机构信息

Department of Cardio-Renal Pathophysiology, Instituto Nacional de Cardiología "Ignacio Chávez", Mexico City 14080, Mexico.

Department of Immunology, Escuela Nacional de Ciencias Biológicas (ENCB), Instituto Politécnico Nacional (IPN), Mexico City 11340, Mexico.

出版信息

Vaccines (Basel). 2023 Mar 14;11(3):655. doi: 10.3390/vaccines11030655.

DOI:10.3390/vaccines11030655

PMID:36992239

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC10055900/

Abstract

It has been 34 months since the beginning of the SARS-CoV-2 coronavirus pandemic, which causes the COVID-19 disease. In several countries, immunization has reached a proportion near what is required to reach herd immunity. Nevertheless, infections and re-infections have been observed even in vaccinated persons. That is because protection conferred by vaccines is not entirely effective against new virus variants. It is unknown how often booster vaccines will be necessary to maintain a good level of protective immunity. Furthermore, many individuals refuse vaccination, and in developing countries, a large proportion of the population has not yet been vaccinated. Some live-attenuated vaccines against SARS-CoV-2 are being developed. Here, we analyze the indirect dispersion of a live-attenuated virus from vaccinated individuals to their contacts and the contribution that this phenomenon could have to reaching Herd Immunity.

摘要

自导致新冠肺炎疾病的新型冠状病毒SARS-CoV-2大流行开始以来，已经过去了34个月。在一些国家，免疫接种率已接近实现群体免疫所需的比例。然而，即使在接种疫苗的人群中也观察到了感染和再次感染的情况。这是因为疫苗提供的保护对新的病毒变种并不完全有效。目前尚不清楚维持良好的保护性免疫力需要多久接种一次加强疫苗。此外，许多人拒绝接种疫苗，在发展中国家，很大一部分人口尚未接种疫苗。一些针对SARS-CoV-2的减毒活疫苗正在研发中。在此，我们分析了减毒活病毒从接种疫苗的个体间接传播给其接触者的情况，以及这一现象对实现群体免疫可能产生的贡献。