Budziło Oskar, Irga-Jaworska Ninela, Myszyńska Marcelina, Malanowska Magdalena, Niedźwiecki Maciej
Department of Paediatrics, Haematology and Oncology, Medical University of Gdańsk, M. Skłodowskiej-Curie 3a Street, 80-210 Gdańsk, Poland.
Vaccines (Basel). 2023 Mar 15;11(3):659. doi: 10.3390/vaccines11030659.
The impact of past COVID-19 infection on the immune system remains unidentified. So far, several papers have revealed the dependence between the count of lymphocytes and their subsets and the outcome of an acute disease. However, still there is little information about long-term consequences, particularly in the pediatric population. We attempted to verify whether a dysregulation of the immune system may be the reason for observed complications after past COVID-19 infection. Hence, we tried to prove that abnormalities in lymphocyte subpopulations are found in patients a certain time after the COVID-19 infection. In our paper, we enrolled 466 patients after SARS-CoV-2 infection, and evaluated their subsets of lymphocytes within 2-12 months after infection and compared them to the control group assessed several years before the pandemic. It occurred that main differences are observed in CD19 lymphocytes and the index CD4/CD8 lymphocytes. We believe that this is only the introduction to further investigation of the immune system of pediatric patients post-COVID-19 infection.
既往新冠病毒感染对免疫系统的影响尚不清楚。到目前为止，已有多篇论文揭示了淋巴细胞及其亚群计数与急性疾病结局之间的相关性。然而，关于长期后果的信息仍然很少，尤其是在儿科人群中。我们试图验证免疫系统失调是否可能是既往新冠病毒感染后出现并发症的原因。因此，我们试图证明在新冠病毒感染后的特定时间，患者体内淋巴细胞亚群存在异常。在我们的研究中，我们招募了466例感染SARS-CoV-2后的患者，在感染后2至12个月内评估了他们的淋巴细胞亚群，并将其与疫情爆发前几年评估的对照组进行了比较。结果发现，CD19淋巴细胞和CD4/CD8淋巴细胞指数存在主要差异。我们认为，这只是对新冠病毒感染后儿科患者免疫系统进一步研究的开端。
