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用于动物和人类的下一代减毒活裂谷热疫苗的前景

Perspectives of Next-Generation Live-Attenuated Rift Valley Fever Vaccines for Animal and Human Use.

作者信息

Wichgers Schreur Paul J, Bird Brian H, Ikegami Tetsuro, Bermúdez-Méndez Erick, Kortekaas Jeroen

机构信息

Department of Virology and Molecular Biology, Wageningen Bioveterinary Research, Wageningen University & Research, 8221 RA Lelystad, The Netherlands.

BunyaVax B.V., 8221 RA Lelystad, The Netherlands.

出版信息

Vaccines (Basel). 2023 Mar 21;11(3):707. doi: 10.3390/vaccines11030707.

DOI:10.3390/vaccines11030707
PMID:36992291
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC10054419/
Abstract

Live-attenuated Rift Valley fever (RVF) vaccines transiently replicate in the vaccinated host, thereby effectively initiating an innate and adaptive immune response. Rift Valley fever virus (RVFV)-specific neutralizing antibodies are considered the main correlate of protection. Vaccination with classical live-attenuated RVF vaccines during gestation in livestock has been associated with fetal malformations, stillbirths, and fetal demise. Facilitated by an increased understanding of the RVFV infection and replication cycle and availability of reverse genetics systems, novel rationally-designed live-attenuated candidate RVF vaccines with improved safety profiles have been developed. Several of these experimental vaccines are currently advancing beyond the proof-of-concept phase and are being evaluated for application in both animals and humans. We here provide perspectives on some of these next-generation live-attenuated RVF vaccines and highlight the opportunities and challenges of these approaches to improve global health.

摘要

减毒活裂谷热（RVF）疫苗在接种宿主中短暂复制，从而有效启动先天性和适应性免疫反应。裂谷热病毒（RVFV）特异性中和抗体被认为是主要的保护关联因素。在牲畜妊娠期使用经典减毒活RVF疫苗进行接种与胎儿畸形、死产和胎儿死亡有关。随着对RVFV感染和复制周期的了解增加以及反向遗传学系统的可用性，已开发出具有改善安全性的新型合理设计的减毒活候选RVF疫苗。其中几种实验性疫苗目前已超越概念验证阶段，并正在动物和人类中进行应用评估。我们在此提供对其中一些下一代减毒活RVF疫苗的见解，并强调这些方法在改善全球健康方面的机遇和挑战。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c169/10054419/c093ee62f473/vaccines-11-00707-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c169/10054419/c093ee62f473/vaccines-11-00707-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c169/10054419/c093ee62f473/vaccines-11-00707-g001.jpg

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