Preza P C, Moura C, Leite Filho A, Cavallari V, Nüdemberg F, Piaia F
J Int Med Res. 1986;14(2):101-4. doi: 10.1177/030006058601400209.
A combination of trimethoprim (TMP) 250 mg and sulfametopyrazine (SMP) 200 mg (dose ratio 5:4) in capsules was administered to ten patients undergoing hysterectomy for uterine leiomyoma. Each patient received a total of 3 of these Kelfiprim capsules: 2 capsules in a single administration 36 hours before surgery and 1 capsule 24 hours later. TMP and SMP concentrations were analyzed in plasma and also in the ovary, Fallopian tube and uterus, removed during surgery. The results indicated that in the reproductive organs of the female genital tract TMP reaches the same concentrations as in plasma. In contrast SMP is 3 to 3.5 times less concentrated in these tissues compared with plasma. At the TMP/SMP ratios obtained in these various organs synergism of the two compounds is reported to be particularly prominent for most bacterial strains. These findings indicate that this TMP-SMP combination may be useful in the treatment of female reproductive tract infections.
将含有250毫克甲氧苄啶（TMP）和200毫克磺胺甲氧嗪（SMP）（剂量比5:4）的胶囊组合给予10名因子宫平滑肌瘤接受子宫切除术的患者。每位患者总共服用3粒这些复方磺胺甲恶唑胶囊：手术前36小时单次服用2粒胶囊，24小时后再服用1粒胶囊。对手术中切除的血浆、卵巢、输卵管和子宫中的TMP和SMP浓度进行了分析。结果表明，在女性生殖道的生殖器官中，TMP达到与血浆中相同的浓度。相比之下，这些组织中SMP的浓度比血浆低3至3.5倍。据报道，在这些不同器官中获得的TMP/SMP比例下，这两种化合物对大多数细菌菌株的协同作用尤为突出。这些发现表明，这种TMP-SMP组合可能对治疗女性生殖道感染有用。
