Gündoğdu Yasemin, Anaforoğlu İnan
School of Medicine, Department of Internal Medicine, Acıbadem Mehmet Ali Aydınlar University, Istanbul, Turkey.
School of Medicine, Department of Endocrinology and Metabolism, Acıbadem Mehmet Ali Aydınlar University, Istanbul, Turkey.
Front Clin Diabetes Healthc. 2022 Feb 23;3:826383. doi: 10.3389/fcdhc.2022.826383. eCollection 2022.
Diabetes is a systemic metabolic disease with serious complications that cause significant stress on the healthcare system. Diabetic kidney disease is the primary cause of end stage renal disease globally and its progression is accelerated by various factors. Another major healthcare hazard is tobacco consumption and smoking has deleterious effects on renal physiology. Prominent factors are defined as sympathetic activity, atherosclerosis, oxidative stress and dyslipidemia. This review aims to enlighten the mechanism underlying the cumulative negative effect of simultaneous exposure to hyperglycemia and nicotine.
糖尿病是一种全身性代谢疾病，伴有严重并发症，给医疗系统带来巨大压力。糖尿病肾病是全球终末期肾病的主要原因，其进展会因多种因素而加速。另一个主要的健康危害是烟草消费，吸烟对肾脏生理有有害影响。主要因素包括交感神经活动、动脉粥样硬化、氧化应激和血脂异常。本综述旨在阐明同时暴露于高血糖和尼古丁所产生的累积负面影响的潜在机制。
