Geteneh Alene, Biset Sirak, Reta Melese Abate
Department of Medical Laboratory Science, College of Health Sciences, Woldia University, Woldia, Ethiopia.
Department of Medical Microbiology, School of Biomedical and Laboratory Sciences, College of Medicine and Health Sciences, University of Gondar, Gondar, Ethiopia.
JAC Antimicrob Resist. 2025 Feb 21;7(1):dlaf020. doi: 10.1093/jacamr/dlaf020. eCollection 2025 Feb.
The emergence of β-lactam non-susceptibility in (GAS) or represents a major challenge for the global public health, particularly in resource-limited settings like Ethiopia. GAS, a primary cause of pharyngitis and invasive infections, is conventionally treated with β-lactam antibiotics such as penicillin. However, the recent evidence raises concerns about the treatment efficacy with reduced susceptibility, the diagnostic limitations, and the potential for complications such as acute rheumatic fever. This commentary calls for attention to the antimicrobial resistance trends in Ethiopian GAS isolates, underscoring the need for routine susceptibility testing, advanced molecular diagnostics, and strengthened laboratory capacities to guide effective treatment strategies and mitigate the antibiotic resistance-associated risks.
A群链球菌（GAS）或肺炎链球菌中β-内酰胺不敏感的出现对全球公共卫生构成了重大挑战，尤其是在埃塞俄比亚这样资源有限的地区。GAS是咽炎和侵袭性感染的主要病因，传统上用青霉素等β-内酰胺类抗生素治疗。然而，最近的证据引发了人们对敏感性降低时治疗效果、诊断局限性以及急性风湿热等并发症可能性的担忧。本评论呼吁关注埃塞俄比亚GAS分离株中的抗菌药物耐药趋势，强调需要进行常规药敏试验、先进的分子诊断以及加强实验室能力，以指导有效的治疗策略并降低与抗生素耐药相关的风险。
