Solanki Jayesh D, Doshi Rishita D, Virani Neel R, Sheth Nidhi S, Dhamecha Jatin K, Shah Chinmay J
Department of Physiology, Govt Medical College, Bhavnagar, Gujarat, India.
Postgraduate Student in Pathology Department, BJ Medical College, Ahmedabad, Gujarat, India.
J Family Med Prim Care. 2022 Nov;11(11):7055-7059. doi: 10.4103/jfmpc.jfmpc_540_22. Epub 2022 Dec 16.
Diabetic peripheral neuropathy (DPN) is common microvascular complication with lack of data from many regions. Vibration perception threshold (VPT) is an objective tool to screen vibration-based neuropathy both quantitatively and qualitatively. We studied prevalence that correlates VPT in diabetic sample population.
A cross-sectional study was performed in 100 under treatment urban type 2 diabetics. Using bioesthesiometer, we tested VPT from sole of lower limbs of each participant. VPT >25 was considered as DPN. VPT was further correlated to determinants using test, chi square, and multiple linear regressions. < 0.05 was taken as statistically significant.
Mean age was 57, mean duration was 9.42 years, 40% were good glycemic, 28% were symptomatic for neuropathy, half subjects had co-existing hypertension and positive family history. VPT >25 was prevalent in 38% participants and mild, moderate, severe grades of DPN were present in 10%, 20%, 38%, respectively. VPT was associated with all three measures of glycemic control both quantitatively and qualitatively imposing significant odds risk (3.45, 2.63, 3.63 for HbA1C, FPG, 2hPG, respectively). Presence of symptoms, duration, and family history were significant predictors of VPT, whereas age, gender, hypertension, hyperlipidemia, and glycemic control were not.
In chronic type 2 diabetics from a city Gujarat, we report 38% prevalence of DPN, related to symptoms, duration, family history, and all measures of glycemic triad. Unrelated to age and gender, VPT is superior to symptoms to detect DPN and it should be used optimally to insinuate timely preventive measures.
糖尿病周围神经病变（DPN）是一种常见的微血管并发症，许多地区缺乏相关数据。振动觉阈值（VPT）是一种从定量和定性两方面筛查基于振动的神经病变的客观工具。我们研究了糖尿病样本人群中与VPT相关的患病率。
对100名正在接受治疗的城市2型糖尿病患者进行了一项横断面研究。使用生物感觉测量仪，我们测试了每位参与者下肢足底的VPT。VPT>25被视为DPN。使用检验、卡方检验和多元线性回归进一步将VPT与决定因素相关联。P<0.05被认为具有统计学意义。
平均年龄为57岁，平均病程为9.42年，40%的患者血糖控制良好，28%的患者有神经病变症状，一半的受试者同时患有高血压且有阳性家族史。38%的参与者VPT>25，轻度、中度、重度DPN分别占10%、20%、38%。VPT在定量和定性方面均与血糖控制的所有三项指标相关，具有显著的优势风险（糖化血红蛋白、空腹血糖、餐后2小时血糖的优势比分别为3.45、2.63、3.63）。症状的存在、病程和家族史是VPT的重要预测因素，而年龄、性别、高血压、高脂血症和血糖控制则不是。
在古吉拉特邦一个城市的慢性2型糖尿病患者中，我们报告DPN的患病率为38%，与症状、病程、家族史以及血糖三联征的所有指标相关。VPT与年龄和性别无关，在检测DPN方面优于症状，应优化使用以及时采取预防措施。
