S Gowtham, Vm Anantha Eashwar, Thozhanenjan Ilamilaval, Cm Nikhil, Narayanan Kiruthika
Community Medicine, Sree Balaji Medical College and Hospital, Chennai, IND.
Cureus. 2025 May 6;17(5):e83586. doi: 10.7759/cureus.83586. eCollection 2025 May.
Background Diabetic peripheral neuropathy (DPN) is a common diabetic consequence that damages nerves and results in pain, numbness, and sensory loss. It has no known treatment, impairs mobility, and increases the risk of foot ulcers; therefore, early therapy is necessary. The objective of this study was to determine the factors associated with DPN in individuals with type 2 diabetes mellitus (T2DM). Methodology A cross-sectional study was conducted from July 2024 to December 2024 among 310 people who attended the diabetic outpatient department (OPD) of a tertiary care hospital in Chengalpattu district. The Neuropathy Disability Score (NDS), Neuropathy Symptom Score (NSS), and Morisky Medication Adherence Scale-8 (MMAS-8) were used, and data were collected and analyzed using IBM SPSS Statistics for Windows, V. 25.0 (IBM Corp., Armonk, NY, USA). Analytical tests such as the chi-squared test and odds ratio were used to find an association between DPN and its associated variables such as age, sex, glycated hemoglobin (HbA1c), and the duration of illness following which the enter method of logistic regression analysis was performed. Results Out of 310 participants, the prevalence of DPN was found to be present in 88 (28.4%). DPN was found to be significantly associated with education (adjusted odds ratio (AOR): 0.33, 95%CI: 0.15-0.74), marital status (AOR: 2.88, 95%CI: 1.52-5.47), comorbidities (AOR: 2.07, 95%CI: 1.05-4.08), and type of medication (AOR: 2.59, 95%CI: 1.29-5.21). Conclusion About 88 (28.4%) of people had DPN; those who were hypertensive and used insulin to control their DM were at a greater risk. Routine screening and control of blood sugar and blood pressure are essential for patients with DM.
背景 糖尿病周围神经病变(DPN)是一种常见的糖尿病并发症,会损害神经,导致疼痛、麻木和感觉丧失。目前尚无已知的治疗方法,它会影响行动能力,并增加足部溃疡的风险;因此,早期治疗很有必要。本研究的目的是确定2型糖尿病(T2DM)患者中与DPN相关的因素。
方法 2024年7月至2024年12月,在金奈帕图区一家三级护理医院的糖尿病门诊就诊的310人中进行了一项横断面研究。使用神经病变残疾评分(NDS)、神经病变症状评分(NSS)和Morisky药物依从性量表-8(MMAS-8),并使用IBM SPSS Statistics for Windows,V. 25.0(美国纽约州阿蒙克市IBM公司)收集和分析数据。使用卡方检验和比值比等分析测试来找出DPN与其相关变量(如年龄、性别、糖化血红蛋白(HbA1c)和病程)之间的关联,之后进行逻辑回归分析的进入法。
结果 在310名参与者中,发现88人(28.4%)患有DPN。发现DPN与教育程度(调整后的比值比(AOR):0.33,95%置信区间:0.15 - 0.74)、婚姻状况(AOR:2.88,95%置信区间:1.52 - 5.47)、合并症(AOR:2.07,95%置信区间:1.05 - 4.08)和药物类型(AOR:2.59,95%置信区间:1.29 - 5.21)显著相关。
结论 约88人(28.4%)患有DPN;高血压且使用胰岛素控制糖尿病的患者风险更高。对糖尿病患者进行常规血糖和血压筛查及控制至关重要。