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牙周炎患者和健康个体龈沟液及唾液中碱性磷酸酶的评估。

Evaluation of alkaline phosphatase in gingival crevicular fluid and saliva of patients with periodontitis and healthy individuals.

作者信息

Rasaei Neda, Ghadiri Ataollah, Peighan Maryam, Rekabi Atefe, Atashkar Nastaran

机构信息

Department of Periodontology, School of Dentistry, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran.

Department of Immunology, School of Medicine, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran.

出版信息

J Family Med Prim Care. 2022 Nov;11(11):6983-6987. doi: 10.4103/jfmpc.jfmpc_477_22. Epub 2022 Dec 16.

DOI:10.4103/jfmpc.jfmpc_477_22
PMID:36992995
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC10041263/
Abstract

INTRODUCTION

In recent decades, biomarkers have been used to predict the progression of chronic periodontitis. One of these biomarkers is alkaline phosphatase (ALP). Due to limitations of the performed studies, this study was performed to determine the amount of salivary ALP and gingival crevicular fluid in patients with chronic periodontitis and healthy individuals.

MATERIALS AND METHODS

Twenty-three patients with severe chronic periodontitis and 23 healthy individuals referred to the Periodontology Department of Ahvaz Jundishapur School of Dentistry were evaluated in this analytical epidemiological study. Salivary ALP and gingival crevicular fluid (GCF) were measured using ALP measuring kit and Hitachi device.

RESULTS

Mean (standard deviation) of ALP enzyme was 19.43 (12.5) in GCF of patients with chronic periodontitis and 12 (1.48) in the healthy group, and it was 80.17 (23.9) in the saliva of patients with periodontitis and 24.78 (4.37) units per litre in the healthy group. There was a significant difference in the mean of this enzyme in GCF and saliva of patients with chronic periodontitis and healthy individuals ( < 0.001).

CONCLUSION

The results showed that mean of ALP enzyme is significantly higher in GCV and saliva of patients with chronic periodontitis than in healthy individuals. Therefore, it seems that this parameter can be used as a useful biochemical parameter for the diagnosis of periodontal disease.

摘要

引言

近几十年来，生物标志物已被用于预测慢性牙周炎的进展。其中一种生物标志物是碱性磷酸酶（ALP）。由于已开展研究存在局限性，本研究旨在测定慢性牙周炎患者和健康个体唾液碱性磷酸酶及龈沟液的含量。

材料与方法

在这项分析性流行病学研究中，对转诊至阿瓦士·君迪沙普尔牙科学院牙周病科的23例重度慢性牙周炎患者和23名健康个体进行了评估。使用碱性磷酸酶检测试剂盒和日立设备测量唾液碱性磷酸酶和龈沟液（GCF）。

结果

慢性牙周炎患者龈沟液中碱性磷酸酶（ALP）酶的平均（标准差）值为19.43（12.5），健康组为12（1.48）；牙周炎患者唾液中该酶的值为80.17（23.9），健康组为24.78（4.37）单位/升。慢性牙周炎患者与健康个体龈沟液和唾液中该酶的平均值存在显著差异（<0.001）。

结论

结果表明，慢性牙周炎患者龈沟液和唾液中碱性磷酸酶（ALP）酶的平均值显著高于健康个体。因此，该参数似乎可作为诊断牙周疾病的有用生化参数。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/70c6/10041263/d2b62a62a354/JFMPC-11-6983-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/70c6/10041263/af01a53baf35/JFMPC-11-6983-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/70c6/10041263/d2b62a62a354/JFMPC-11-6983-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/70c6/10041263/af01a53baf35/JFMPC-11-6983-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/70c6/10041263/d2b62a62a354/JFMPC-11-6983-g002.jpg

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2
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J Indian Soc Periodontol. 2012 Oct;16(4):513-8. doi: 10.4103/0972-124X.106889.
3
Evaluating the levels of salivary alkaline and acid phosphatase activities as biochemical markers for periodontal disease: A case series.
Biomolecules. 2024 Jul 1;14(7):787. doi: 10.3390/biom14070787.
4
A preliminary study on calcifying nanoparticles in dental plaque: Isolation, characterization, and potential mineralization mechanism.牙菌斑中钙化纳米颗粒的初步研究：分离、表征和潜在的矿化机制。
Clin Exp Dent Res. 2024 Jun;10(3):e885. doi: 10.1002/cre2.885.
评估唾液碱性磷酸酶和酸性磷酸酶活性水平作为牙周病生化标志物：病例系列研究
Dent Res J (Isfahan). 2012 Jan;9(1):41-5. doi: 10.4103/1735-3327.92942.
4
Salivary biomarkers for predicting the progression of chronic periodontitis.唾液生物标志物预测慢性牙周炎的进展。
Arch Oral Biol. 2012 Apr;57(4):413-20. doi: 10.1016/j.archoralbio.2011.09.011. Epub 2011 Oct 24.
5
Serum alkaline phosphatase: a potential marker in the progression of periodontal disease in cirrhosis patients.
Quintessence Int. 2011 Apr;42(4):345-8.
6
Alkaline phosphatase as a periodontal disease marker.碱性磷酸酶作为一种牙周疾病标志物。
Indian J Dent Res. 2010 Oct-Dec;21(4):531-6. doi: 10.4103/0970-9290.74209.
7
Salivary enzymes and periodontal disease.唾液酶与牙周疾病
Med Oral Patol Oral Cir Bucal. 2006 Mar 1;11(2):E115-9.