Colston Josh M, Chernyavskiy Pavel, Gardner Lauren, Nong Malena, Fang Bin, Houpt Eric, Swarup Samarth, Badr Hamada, Zaitchik Benjamin, Lakshmi Venkataraman, Kosek Margaret
University of Virginia School of Medicine.
Johns Hopkins University.
Res Sq. 2024 Jan 10:rs.3.rs-2640564. doi: 10.21203/rs.3.rs-2640564/v3.
Diarrhea remains a leading cause of childhood illness throughout the world that is increasing due to climate change and is caused by various species of ecologically sensitive pathogens. The emerging Planetary Health movement emphasizes the interdependence of human health with natural systems, and much of its focus has been on infectious diseases and their interactions with environmental and human processes. Meanwhile, the era of big data has engendered a public appetite for interactive web-based dashboards for infectious diseases. However, enteric infectious diseases have been largely overlooked by these developments.
The Planetary Child Health and Enterics Observatory (Plan-EO) is a new initiative that builds on existing partnerships between epidemiologists, climatologists, bioinformaticians, and hydrologists as well as investigators in numerous low- and middle-income countries. Its objective is to provide the research and stakeholder community with an evidence base for the geographical targeting of enteropathogen-specific child health interventions such as novel vaccines. The initiative will produce, curate, and disseminate spatial data products relating to the distribution of enteric pathogens and their environmental and sociodemographic determinants.
As climate change accelerates there is an urgent need for etiology-specific estimates of diarrheal disease burden at high spatiotemporal resolution. Plan-EO aims to address key challenges and knowledge gaps by making rigorously obtained, generalizable disease burden estimates freely available and accessible to the research and stakeholder communities. Pre-processed environmental and EO-derived spatial data products will be housed, continually updated, and made publicly available to the research and stakeholder communities both within the webpage itself and for download. These inputs can then be used to identify and target priority populations living in transmission hotspots and for decision-making, scenario-planning, and disease burden projection.
PROSPERO protocol #CRD42023384709.
腹泻仍然是全球儿童疾病的主要原因，由于气候变化，腹泻病例正在增加，且由多种对生态敏感的病原体引起。新兴的行星健康运动强调人类健康与自然系统的相互依存关系，其重点大多放在传染病及其与环境和人类活动的相互作用上。与此同时，大数据时代引发了公众对基于网络的交互式传染病仪表盘的兴趣。然而，肠道传染病在很大程度上被这些发展所忽视。
行星儿童健康与肠道疾病观测站（Plan-EO）是一项新倡议，它建立在流行病学家、气候学家、生物信息学家、水文学家以及众多低收入和中等收入国家的研究人员之间现有的合作关系基础之上。其目标是为研究和利益相关者群体提供一个证据基础，以便针对特定肠道病原体的儿童健康干预措施（如新型疫苗）进行地理定位。该倡议将制作、整理和传播与肠道病原体分布及其环境和社会人口学决定因素相关的空间数据产品。
随着气候变化加速，迫切需要在高时空分辨率下对腹泻病负担进行病因特异性估计。Plan-EO旨在通过使严格获得的、可推广的疾病负担估计值免费提供给研究和利益相关者群体，来应对关键挑战和知识空白。经过预处理的环境和EO衍生的空间数据产品将被存储、持续更新，并在网页本身以及供下载，向研究和利益相关者群体公开提供。然后，这些输入可用于识别和定位生活在传播热点地区的优先人群，并用于决策、情景规划和疾病负担预测。
PROSPERO协议编号#CRD42023384709。
