Li Hao, Jin Xin
Molecular Neurobiology Laboratory, The Salk Institute for Biological Studies, 10010 North Torrey Pines Road, La Jolla, CA 92037, USA.
Center for Motor Control and Disease, Key Laboratory of Brain Functional Genomics, East China Normal University, 3663 North Zhongshan Road, Shanghai 200062, China.
bioRxiv. 2023 Jul 22:2023.03.20.533567. doi: 10.1101/2023.03.20.533567.
The basal ganglia are known to be essential for action selection. However, the functional role of basal ganglia direct and indirect pathways in action selection remains unresolved. Here by employing cell-type-specific neuronal recording and manipulation in mice trained in a choice task, we demonstrate that multiple dynamic interactions from the direct and indirect pathways control the action selection. While the direct pathway regulates the behavioral choice in a linear manner, the indirect pathway exerts a nonlinear inverted-U-shaped control over action selection, depending on the inputs and the network state. We propose a new center (direct) - surround (indirect) - context (indirect) "Triple-control" functional model of basal ganglia, which can replicate the physiological and behavioral experimental observations that cannot be simply explained by either the traditional "Go/No-go" or more recent "Co-activation" model. These findings have important implications on understanding the basal ganglia circuitry and action selection in health and disease.
已知基底神经节对于动作选择至关重要。然而，基底神经节直接通路和间接通路在动作选择中的功能作用仍未明确。在此，我们通过在经过选择任务训练的小鼠中采用细胞类型特异性神经元记录和操纵方法，证明直接通路和间接通路的多种动态相互作用控制着动作选择。直接通路以线性方式调节行为选择，而间接通路则根据输入和网络状态对动作选择施加非线性倒U形控制。我们提出了一种新的基底神经节“三重控制”功能模型，即中心（直接）-外周（间接）-情境（间接）模型，该模型可以复制那些无法用传统的“去/不去”模型或最近的“共同激活”模型简单解释的生理和行为实验观察结果。这些发现对于理解健康和疾病状态下的基底神经节神经回路及动作选择具有重要意义。
