Department of Respiratory and Critical Care Medicine, the Second People's Hospital of Hefei, Hefei, People's Republic of China.
Department of Respiratory and Critical Care Medicine, Hefei Hospital Affiliated to Anhui Medical University, Hefei, People's Republic of China.
Int J Chron Obstruct Pulmon Dis. 2023 Mar 23;18:399-406. doi: 10.2147/COPD.S400985. eCollection 2023.
To investigate the potential of plasma microRNA-150-5p (miR-150-5p) as a biomarker for chronic obstructive pulmonary disease (COPD) and its relationship with clinical indicators such as pulmonary function.
Fifty-nine patients with COPD and twenty-six healthy control individuals were recruited in the Second People's Hospital of Hefei from September 2021 to September 2022. The plasma expression level of miR-150-5p was measured by quantitative real-time polymerase chain reaction.
The miR-150-5p level in the COPD group was significantly lower than that in the control group, and the relative expression was lower in patients with severe airflow limitation than those with mild limitation. Plasma miR-150-5p levels were positively correlated with pulmonary function indicators and negatively correlated with the white blood cell count and C-reactive protein level. The receiver operating characteristic curve suggested that plasma miR-150-5p had predictive value for COPD (area under curve = 0.819, sensitivity 64.4%, specificity 92.3%).
MiR-150-5p can be useful for the diagnosis and disease assessment of COPD, and has value as a biomarker for COPD.
探讨血浆微小 RNA-150-5p（miR-150-5p）作为慢性阻塞性肺疾病（COPD）生物标志物的潜力及其与肺功能等临床指标的关系。
2021 年 9 月至 2022 年 9 月，在合肥市第二人民医院招募了 59 例 COPD 患者和 26 名健康对照者。采用实时定量聚合酶链反应测定血浆 miR-150-5p 的表达水平。
COPD 组 miR-150-5p 水平明显低于对照组，严重气流受限患者的相对表达水平低于轻度气流受限患者。血浆 miR-150-5p 水平与肺功能指标呈正相关，与白细胞计数和 C 反应蛋白水平呈负相关。受试者工作特征曲线提示血浆 miR-150-5p 对 COPD 具有预测价值（曲线下面积=0.819，灵敏度 64.4%，特异性 92.3%）。
miR-150-5p 可用于 COPD 的诊断和疾病评估，具有作为 COPD 生物标志物的价值。
