Cancer Center, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China.
Front Immunol. 2023 Mar 13;14:1073561. doi: 10.3389/fimmu.2023.1073561. eCollection 2023.
Generally, the demise of cancer cells in different ways enables the body to clear these harmful cells. However, cancer cells obtain unlimited replication and immortality from successful circumvention of cell death various mechanisms. Some evidence suggests that treatment-induced dying tumor cells even promote cancer progression. Notably, therapeutic interventions to harness the immune system against tumor cells have shown complicated influences in clinics. Herein, there is an urgent need to clarify the underlying mechanisms that influence the outcome and regulation of the immune system during cancer treatment. In this review, we provide an account on the cell death modes and the relationship between dying tumor cells with tumor immune microenvironment during cancer treatment, focusing on immunotherapy, from mechanistic standpoint to emerging limitations and future directions.
一般来说，癌细胞以不同的方式死亡可以使身体清除这些有害细胞。然而，癌细胞通过成功规避细胞死亡的各种机制获得了无限的复制和永生。有证据表明，治疗诱导的肿瘤细胞死亡甚至促进了癌症的进展。值得注意的是，利用免疫系统对抗肿瘤细胞的治疗干预在临床上显示出了复杂的影响。因此，迫切需要阐明影响癌症治疗过程中免疫系统结果和调节的潜在机制。在这篇综述中，我们从机制的角度出发，针对目前免疫疗法的局限性和未来的发展方向，阐述了在癌症治疗过程中细胞死亡方式以及死亡肿瘤细胞与肿瘤免疫微环境之间的关系。
