Akimoto Y, Komiya M, Kaneko K, Fujii A, Tamura T
J Oral Maxillofac Surg. 1986 Feb;44(2):107-12. doi: 10.1016/0278-2391(86)90191-6.
Ninety-six patients who underwent the extraction of impacted mandibular third molars in a nonfasting state were given a single oral dose of bacampicillin preoperatively. Specimens of serum from venous blood (n = 107), gingiva (n = 57), mandibular bone (n = 68), dental follicle (n = 56), and dental pulp (n = 43) were obtained during the operation and assayed for ampicillin content. The mean peak concentrations in serum, gingiva, mandibular bone, dental follicle, and dental pulp all occurred approximately 90 minutes after administration. The concentration ratios of the tissues to the corresponding serum at the peak time were 0.50, 0.20, 0.34, and 0.61, respectively. Bacampicillin showed good absorption by the intestine, and sufficient concentrations of the resulting metabolite, ampicillin, were found in the oral tissues.
96例在非禁食状态下接受下颌阻生第三磨牙拔除术的患者在术前口服单剂量的巴氨西林。术中采集静脉血血清样本（n = 107）、牙龈样本（n = 57）、下颌骨样本（n = 68）、牙囊样本（n = 56）和牙髓样本（n = 43），并检测氨苄西林含量。血清、牙龈、下颌骨、牙囊和牙髓中的平均峰值浓度均在给药后约90分钟出现。峰值时组织与相应血清的浓度比分别为0.50、0.20、0.34和0.61。巴氨西林在肠道吸收良好，口服组织中发现了足够浓度的代谢产物氨苄西林。
