儿科胃肠病学中 Alpha-Gal 综合征的临床表现及对哺乳动物饮食消除的反应。
Clinical Presentation of Alpha-Gal Syndrome in Pediatric Gastroenterology and Response to Mammalian Dietary Elimination.
机构信息
Pediatric Gastroenterology, Hepatology, and Nutrition, Vanderbilt University Medical Center, Nashville, Tennessee, USA.
Division of Allergy, Pulmonary, and Critical Care Medicine, Department of Medicine, Vanderbilt University Medical Center, Nashville, Tennessee, USA.
出版信息
Am J Gastroenterol. 2023 Jul 1;118(7):1293-1296. doi: 10.14309/ajg.0000000000002268. Epub 2023 Mar 28.
INTRODUCTION
Alpha-gal syndrome is an immunoglobulin E (IgE)-mediated delayed hypersensitivity reaction to nonprimate mammalian products, which has a newly established gastrointestinal (GI) phenotype in adults. We assessed the GI presentation and treatment response in children.
METHODS
This is a retrospective study of patients presenting in a pediatric gastroenterology clinic tested for alpha-gal IgE.
RESULTS
Forty of 199 patients (20%) tested had a positive alpha-gal-specific IgE, with 77.5% reporting GI symptoms in isolation. Of the 30 that attempted dietary elimination, 8 (27%) experienced full resolution of symptoms.
DISCUSSION
Alpha-gal syndrome can present with isolated GI symptoms in children.
简介
α-半乳糖综合征是一种免疫球蛋白 E（IgE）介导的迟发性超敏反应，针对非灵长类哺乳动物产品，在成人中具有新确立的胃肠道（GI）表型。我们评估了儿童的 GI 表现和治疗反应。
方法
这是一项在儿科胃肠病学诊所就诊的患者进行α-半乳糖 IgE 检测的回顾性研究。
结果
在 199 名接受检测的患者中，有 40 名（20%）的α-半乳糖特异性 IgE 呈阳性，其中 77.5%的患者仅报告有 GI 症状。在尝试饮食排除的 30 名患者中，有 8 名（27%）的症状完全缓解。
讨论
α-半乳糖综合征可在儿童中出现孤立性 GI 症状。
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