Department of Pathology, Microbiology, and Immunology, School of Veterinary Medicine, University of California Davis, Davis, California, United States of America.
Division of Virology, Department of Pathology, University of Cambridge, Cambridge, United Kingdom.
PLoS One. 2023 Mar 30;18(3):e0283049. doi: 10.1371/journal.pone.0283049. eCollection 2023.
From 2011-2018, we conducted surveillance in marine mammals along the California coast for influenza A virus (IAV), frequently detecting anti-influenza antibodies and intermittently detecting IAV. In spring 2019, this pattern changed. Despite no change in surveillance intensity, we detected IAV RNA in 10 samples in March and April, mostly in nasal and rectal swabs from northern elephant seals (Mirounga angustirostris). Although virus isolation was unsuccessful, IAV sequenced from one northern elephant seal nasal swab showed close genetic identity with pandemic H1N1 IAV subclade 6B.1A.1 that was concurrently circulating in humans in the 2018/19 influenza season. This represents the first report of human A(H1N1)pdm09 IAV in northern elephant seals since 2010, suggesting IAV continues to spill over from humans to pinnipeds.
从 2011 年至 2018 年，我们对加利福尼亚沿海的海洋哺乳动物进行了流感病毒 A（IAV）监测，经常检测到抗流感抗体，并间歇性地检测到 IAV。2019 年春季，这种模式发生了变化。尽管监测强度没有变化，但我们在 3 月和 4 月的 10 个样本中检测到了 IAV RNA，主要来自北象海豹（Mirounga angustirostris）的鼻拭子和直肠拭子。尽管病毒分离不成功，但从一只北象海豹的鼻拭子中分离出的 IAV 与在 2018/19 流感季节同时在人群中流行的大流行性 H1N1 IAV 亚系 6B.1A.1 具有密切的遗传同源性。这是自 2010 年以来首次在北象海豹中报告人 A（H1N1）pdm09 IAV，表明 IAV 继续从人类传播给鳍足类动物。
