Centre de recherche du Centre hospitalier de l'Université de Montréal (CRCHUM), Montreal, Canada; Institut du cancer de Montréal, Montreal, Canada.
Rosalind and Morris Goodman Cancer Institute, McGill University, Montreal, Canada.
Eur J Cell Biol. 2023 Jun;102(2):151313. doi: 10.1016/j.ejcb.2023.151313. Epub 2023 Mar 24.
The small GTPase RhoB is distinguished from other Rho proteins by its unique subcellular localization in endosomes, multivesicular bodies, and nucleus. Despite high sequence homology with RhoA and RhoC, RhoB is mainly associated with tumor suppressive function, while RhoA and RhoC support oncogenic transformation in most malignancies. RhoB regulates the endocytic trafficking of signaling molecules and cytoskeleton remodeling, thereby controlling growth, apoptosis, stress response, immune function, and cell motility in various contexts. Some of these functions may be ascribed to RhoB's unique subcellular localization to endocytic compartments. Here we describe the pleiotropic roles of RhoB in cancer suppression in the context of its subcellular localization, and we discuss possible therapeutic avenues to pursue and highlight priorities for future research.
小分子 GTP 酶 RhoB 因其独特的亚细胞定位（内体、多泡体和细胞核）而与其他 Rho 蛋白区分开来。尽管与 RhoA 和 RhoC 具有高度的序列同源性，但 RhoB 主要与肿瘤抑制功能相关，而 RhoA 和 RhoC 在大多数恶性肿瘤中支持致癌转化。RhoB 调节信号分子的内吞运输和细胞骨架重塑，从而在各种情况下控制生长、凋亡、应激反应、免疫功能和细胞迁移。其中一些功能可能归因于 RhoB 独特的亚细胞定位到内吞小体。本文描述了 RhoB 在癌症抑制中的多效性作用及其亚细胞定位，讨论了可能的治疗途径，并强调了未来研究的优先事项。
