从白术中分离得到的 6 个炔类化合物及其抗结肠癌活性。
Six polyacetylenes from Atractylodes macrocephala Koidz and their anti-colon cancer activity.
机构信息
The MOE Key Laboratory of Standardization of Chinese Medicines, Institute of Chinese Materia Medica, Shanghai University of Traditional Chinese Medicine, Shanghai 201203, China.
The MOE Key Laboratory of Standardization of Chinese Medicines, Institute of Chinese Materia Medica, Shanghai University of Traditional Chinese Medicine, Shanghai 201203, China; Shanghai R&D Center for Standardization of Chinese Medicine, Shanghai 201203, China.
出版信息
Fitoterapia. 2023 Jun;167:105490. doi: 10.1016/j.fitote.2023.105490. Epub 2023 Mar 28.
Six undescribed polyacetylenes Atracetylenes A-F (1-6) and three known ones (7-9) were isolated from the rhizomes of Atractylodes macrocephala Koidz.. The comprehensive interpretation of NMR, HR-ESI-MS, DP4+ calculations, and electronic circular dichroism (ECD) calculations resulted in the elucidation of their structures and absolute configurations. The anti-colon cancer activities of (1-9) were evaluated by assaying the cytotoxicity and apoptosis on CT-26 cell lines. Notably, 5 (IC 17.51 ± 1.41 μM) and 7 (IC 18.58 ± 1.37 μM) exhibited significant cytotoxicity, and polyacetylenes 3-6 showed excellent abilities to promote apoptosis of CT-26 cell lines by Annexin V-FITC/PI assay. The results demonstrated that the polyacetylenes in A. macrocephala may be prospective for the treatment of colorectal cancer.
从白术根茎中分离得到了 6 个未被描述的聚乙炔类化合物 Atracetylenes A-F（1-6）和 3 个已知化合物（7-9）。通过综合解析 NMR、HR-ESI-MS、DP4+计算和电子圆二色谱（ECD）计算，阐明了它们的结构和绝对构型。通过 CT-26 细胞系的细胞毒性和细胞凋亡实验评估了（1-9）的抗结肠癌活性。值得注意的是，化合物 5（IC 17.51±1.41 μM）和 7（IC 18.58±1.37 μM）表现出显著的细胞毒性，聚乙炔化合物 3-6 通过 Annexin V-FITC/PI 检测显示出优异的促进 CT-26 细胞系凋亡的能力。结果表明，白术中的聚乙炔类化合物可能是治疗结直肠癌的潜在药物。
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