Department of Nutrition, Faculty of Medicine and Health Sciences, Universiti Putra Malaysia, Selangor, Malaysia.
Department of Nutrition, Faculty of Medicine and Health Sciences, Universiti Putra Malaysia, Selangor, Malaysia. Email:
Asia Pac J Clin Nutr. 2023;32(1):168-182. doi: 10.6133/apjcn.202303_32(1).0020.
Evidence for gene-diet interactions is lacking among individuals with specific dietary practices including vegetarians. This study aimed to determine the interactions of rs174547 in the fatty acid desaturase 1 (FADS1) gene with macronutrient such as carbohydrate (particularly fibre), protein and fat intakes on abdominal obesity among middle-aged Malaysian vegetarians of Chinese and Indian ethnicity.
The present cross-sectional study was conducted among 163 vegetarians in Kuala Lumpur and Selangor, Malaysia. Dietary intakes of vegetarians were assessed by using a food frequency questionnaire. Waist circumference of vegetarians was measured by using a Lufkin tape W606PM. Genotypes of the rs174547 of vegetarians were determined by using Agena® MassARRAY. A multiple logistic regression model was used to determine the interactions of the rs174547 with macronutrient on abdominal obesity.
About 1 in 2 vegetarians (51.5%) had abdominal obesity. Individuals with CT and TT genotype at T3 intake of carbohydrates, protein, fat and fibre as well as individuals with TT genotype at T2 intake of carbohydrates and protein had higher odds of abdominal obesity (pinteration <0.05). The gene-diet interaction remained significant for fibre intake (OR: 4.71, 95% CI: 1.25-17.74, pinteraction=0.022) among vegetarians with TT genotype at T2 intake of fibre after adjusting for age and sex and considering the effects of ethnicity and food groups.
The rs174547 significantly interacted with fibre intake on abdominal obesity. A specific dietary fibre recommendation based on genetics is needed among Chinese and Indian middle-aged vegetarians.
缺乏特定饮食人群（包括素食者）的基因-饮食相互作用的证据。本研究旨在确定脂肪酸去饱和酶 1 (FADS1) 基因中的 rs174547 与碳水化合物（尤其是纤维）、蛋白质和脂肪等宏量营养素的相互作用，对马来西亚华裔和印裔中年素食者腹部肥胖的影响。
本横断面研究在马来西亚吉隆坡和雪兰莪的 163 名素食者中进行。素食者的饮食摄入量通过食物频率问卷进行评估。素食者的腰围通过使用 Lufkin 带 W606PM 进行测量。通过 Agena® MassARRAY 确定素食者 rs174547 的基因型。使用多变量逻辑回归模型确定 rs174547 与宏量营养素对腹部肥胖的相互作用。
大约 1/2 的素食者（51.5%）存在腹部肥胖。在 T3 碳水化合物、蛋白质、脂肪和纤维摄入量中携带 CT 和 TT 基因型的个体以及在 T2 碳水化合物和蛋白质摄入量中携带 TT 基因型的个体，腹部肥胖的几率更高（p 交互 <0.05）。在调整年龄和性别，并考虑种族和食物组的影响后，T2 纤维摄入量中携带 TT 基因型的素食者纤维摄入量的基因-饮食相互作用仍然显著（OR：4.71，95%CI：1.25-17.74，p 交互=0.022）。
rs174547 与纤维摄入量显著相互作用影响腹部肥胖。华裔和印裔中年素食者需要根据遗传学制定特定的膳食纤维推荐量。
