Matsuyama S S, Cripe A T, Joseph J
Hum Hered. 1986;36(2):93-6. doi: 10.1159/000153606.
Previous investigations of the association of haptoglobin (Hp) with dementia of the Alzheimer type (DAT) have reported contradictory results. In the present study, we phenotyped 69 patients clinically diagnosed as having DAT and, for comparison, 64 cognitively intact individuals. We failed to find a significant association between either of the Hp alleles and DAT. Instead, we observed a nonsignificant decrease in the Hp-1 gene frequency in the DAT population (0.34) as compared to our normal elderly comparison group (0.41).
先前关于触珠蛋白（Hp）与阿尔茨海默型痴呆（DAT）关联的研究报告了相互矛盾的结果。在本研究中，我们对69例临床诊断为患有DAT的患者进行了表型分析，并作为对照，对64名认知功能正常的个体进行了分析。我们未发现任何一种Hp等位基因与DAT之间存在显著关联。相反，我们观察到，与正常老年对照组（0.41）相比，DAT人群中Hp-1基因频率出现了不显著的下降（0.34）。
