Matsuyama S S, Joseph J
Hum Hered. 1984;34(2):65-8. doi: 10.1159/000153438.
Haptoglobin (Hp) has been used in association studies with unipolar depression and has led to investigations on the possible association of Hp genotypes with disease. Because of the reported association between the Hp-2 allele and depression we phenotyped 65 elderly patients with unipolar depression and 40 elderly individuals without mental disorders. We failed to find an association between either of the Hp alleles and unipolar depression. The Hp2 gene frequencies for the depressed patients and the comparison group were 0.585 and 0.550, respectively, and these values were not significantly different. Both values were within the gene frequency range reported for Caucasian populations.
触珠蛋白（Hp）已用于与单相抑郁症的关联研究，并引发了对Hp基因型与疾病可能关联的调查。由于有报道称Hp-2等位基因与抑郁症之间存在关联，我们对65名老年单相抑郁症患者和40名无精神障碍的老年人进行了表型分析。我们未能发现Hp等位基因与单相抑郁症之间存在关联。抑郁症患者和对照组的Hp2基因频率分别为0.585和0.550，这些值没有显著差异。两个值均在高加索人群报道的基因频率范围内。
