Salomon R J, Gardepe S F, Woodley D T
Int J Dermatol. 1986 Mar;25(2):109-12. doi: 10.1111/j.1365-4362.1986.tb04550.x.
Subcutaneous nodules with the histopathologic features of rheumatoid nodules can occur in both rheumatic and nonrheumatic diseases. When there is no evidence of systemic disease, they often are classified as deep granuloma annulare. While there are numerous reports of such nodules occurring in children without systemic disease, there are few reports of similarly affected adults. Two adults are described with multiple subcutaneous nodules that were overlying joints and were histologically similar to rheumatoid nodules. Neither patient had other clinical or laboratory manifestations of rheumatic disease. These cases most likely represent an adult form of deep granuloma annulare. The wide clinical spectrum in which similar nodules can occur and their pathogenesis is discussed.
具有类风湿结节组织病理学特征的皮下结节可出现在风湿性和非风湿性疾病中。当没有全身性疾病的证据时，它们通常被归类为深部环状肉芽肿。虽然有许多关于此类结节发生在无全身性疾病儿童中的报道，但关于成人出现类似情况的报道却很少。本文描述了两名成年人，他们有多个位于关节上方的皮下结节，组织学上与类风湿结节相似。两名患者均无风湿性疾病的其他临床或实验室表现。这些病例很可能代表深部环状肉芽肿的成人形式。文中讨论了可能出现类似结节的广泛临床谱及其发病机制。
