Stormorken H, Skalpe I O, Testart M C
Invest Radiol. 1986 Apr;21(4):348-54. doi: 10.1097/00004424-198604000-00011.
An in vitro and in vivo study of the effect of ionic and nonionic contrast media (CM) on coagulation and platelet function is reported. The methods employed were tests for extrinsic and intrinsic coagulation together with a fibrinolytic parameter and aggregation using ADP and collagen as inducers. The in vivo study utilized patients undergoing routine cerebral angiography. The in vitro results showed a modest influence of the nonionic CM in contrast to the ionic. The marked inhibitory effect of the latter was mainly caused by inherent toxicity, osmolality/ionic strength being of minor importance. The in vivo results showed a negligible influence of CM on systemic hemostatic parameters, but catheter-derived samples indicated desirability of premedication with ASA or heparin. The nonionic CM caused less discomfort than the ionic CM.
本文报道了一项关于离子型和非离子型造影剂（CM）对凝血和血小板功能影响的体外和体内研究。所采用的方法包括外源性和内源性凝血测试、纤溶参数检测以及以ADP和胶原作为诱导剂的聚集试验。体内研究使用了接受常规脑血管造影的患者。体外研究结果显示，与离子型造影剂相比，非离子型造影剂的影响较小。离子型造影剂的显著抑制作用主要由其固有毒性引起，渗透压/离子强度的影响较小。体内研究结果显示，造影剂对全身止血参数的影响可忽略不计，但导管采集的样本表明，术前使用阿司匹林或肝素是可取的。非离子型造影剂引起的不适比离子型造影剂少。
