Stormorken H, Testart M C, Braekke G, Sveen K, Jakobsen J A, Grande T, Andrew E
Research Institute for Internal Medicine, Rikshospitalet, University Hospital, Oslo, Norway.
Acta Radiol Suppl. 1987;370:93-6.
The effect on hemostatic parameters of two non-ionic contrast media, iopentol and iohexol in concentrations of 350 mg I/ml, were tested in vitro. The new medium iopentol had similar effects to those of iohexol, both with respect to the intrinsic coagulation system and platelet aggregation. As part of a human pharmacologic study the effects of iopentol on hemostatic parameters were tested in 8 volunteers in vivo. Iopentol induced a slightly decreased coagulability and aggregability in venous blood. It was concluded that the effects were of very little consequence for hemostasis as a whole.
体外测试了两种浓度为350mg I/ml的非离子型造影剂碘普罗胺和碘海醇对止血参数的影响。新型造影剂碘普罗胺在内在凝血系统和血小板聚集方面的作用与碘海醇相似。作为人体药理学研究的一部分，对8名志愿者体内碘普罗胺对止血参数的影响进行了测试。碘普罗胺导致静脉血的凝固性和聚集性略有下降。得出的结论是，总体而言，这些影响对止血的影响很小。
