基于吩噻嗪的荧光探针，用于检测 ClO，具有肉眼可见的颜色变化特性。
A fluorescent probe based on phenothiazine for detection of ClO with naked-eye color change properties.
机构信息
School of Chemistry and Chemical Engineering, Liaoning Normal University, Dalian, Liaoning, 116029, China.
School of Chemistry and Chemical Engineering, Liaoning Normal University, Dalian, Liaoning, 116029, China.
出版信息
Anal Biochem. 2023 Jun 1;670:115131. doi: 10.1016/j.ab.2023.115131. Epub 2023 Mar 29.
Hypochlorite (ClO) plays a key role in life systems and it is necessary to develop an effective detection method. In view of the significant advantages of the fluorescent probe, we have synthesized a naked-eye recognition fluorescent probe NNCF for the detection of ClO based on phenothiazine and naphthalimide. The probe NNCF is sensitive (LOD = 9.5 nM) and fast for ClO (within 30 s), and its Stokes shift is as large as 161 nm. In addition, the probe NNCF has been successfully used for imaging detection of exogenous ClO in MCF-7 cells with low toxicity.
次氯酸根（ClO）在生命体系中起着关键作用，因此有必要开发一种有效的检测方法。鉴于荧光探针的显著优势，我们基于吩噻嗪和萘酰亚胺合成了一种用于检测 ClO 的裸眼识别荧光探针 NNCF。该探针 NNCF 对 ClO 具有较高的灵敏度（LOD=9.5 nM）和较快的响应速度（30 s 内），Stokes 位移高达 161nm。此外，该探针 NNCF 已成功用于 MCF-7 细胞中外源性 ClO 的成像检测，且毒性较低。
Zotero 插件