Shigeoka A O, Hall R T, Hill H R
Infect Immun. 1979 Feb;23(2):438-45. doi: 10.1128/iai.23.2.438-445.1979.
Strains of types II and III group B streptococci do not appear to be uniformly susceptible to opsonization by antibody-containing human sera, as studied using both a chemiluminescence and a radiolabeled bacterial uptake technique. We could not demonstrate a correlation of serum-sensitive or resistant strains with capsular antigen quantities, although serum absorption studies with whole organisms and HCl, trichloroacetic acid, and saline extracts indicated that the antibody to type-specific capsular polysaccharide is important in opsonizing both serum-resistant and serum-sensitive strains. Since trypsin treatment produced significantly enhanced opsonization of serum-resistant and serum-sensitive strains, proteins present on some group B streptococci may be important antiphagocytic factors.
使用化学发光和放射性标记细菌摄取技术进行研究时,II型和III型B组链球菌菌株似乎对含抗体的人血清调理作用并不具有一致的敏感性。尽管对完整生物体以及盐酸、三氯乙酸和盐水提取物进行的血清吸收研究表明,针对型特异性荚膜多糖的抗体在调理血清抗性和血清敏感菌株方面都很重要,但我们无法证明血清敏感或抗性菌株与荚膜抗原量之间存在相关性。由于胰蛋白酶处理显著增强了血清抗性和血清敏感菌株的调理作用,某些B组链球菌上存在的蛋白质可能是重要的抗吞噬因子。