Cleat P H, Coid C R
Br J Exp Pathol. 1982 Aug;63(4):452-7.
An investigation was undertaken into the role of antibody and complement in neutrophil phagocytosis and killing of group B streptococci of low and high pathogenicity. Phagocytosis of both types of organism appears to be a nonspecific event requiring only nonspecific antibody or complement. However, neutrophil bactericidal activity is mediated by the pathogenicity of the infecting organism. Neutrophils alone can kill some streptococci of low pathogenicity, but their killing ability is considerably increased in the presence of specific antibody or complement. An active role for the alternative pathway of complement in the killing process was demonstrated for organisms of low pathogenicity. Neutrophils did not kill the highly pathogenic organisms in the absence of antibody and complement, and required specific antibody, but not complement, to kill these bacteria. The alternative complement pathway is not involved in killing of highly pathogenic organisms. Addition of specific antibody to neutrophils containing ingested bacteria stimulated the neutrophils to kill the intracellular bacteria, suggesting an alternative role for specific antibody in the killing process other than as an opsonin. It is suggested that activation of Fc receptors on the neutrophil surface initiates the bactericidal action of the neutrophils.
对抗体和补体在中性粒细胞吞噬和杀灭低致病性和高致病性B族链球菌中的作用进行了研究。两种类型的细菌的吞噬作用似乎是一个非特异性事件，只需要非特异性抗体或补体。然而，中性粒细胞的杀菌活性由感染细菌的致病性介导。单独的中性粒细胞可以杀死一些低致病性的链球菌，但在存在特异性抗体或补体的情况下，它们的杀伤能力会显著增强。对于低致病性细菌，已证明补体替代途径在杀伤过程中发挥积极作用。在没有抗体和补体的情况下，中性粒细胞不能杀死高致病性细菌，并且需要特异性抗体而非补体来杀死这些细菌。补体替代途径不参与高致病性细菌的杀伤。向含有已吞噬细菌的中性粒细胞中添加特异性抗体可刺激中性粒细胞杀死细胞内细菌，这表明特异性抗体在杀伤过程中除作为调理素外还具有其他作用。有人认为中性粒细胞表面Fc受体的激活启动了中性粒细胞的杀菌作用。
