Department of Ophthalmology, Eye Diseases and Optometry Institute, Peking University People's Hospital, Beijing, 100044, China.
Beijing Key Laboratory of Diagnosis and Therapy of Retinal and Choroid Diseases, College of Optometry, Peking University Health Science Center, Beijing, China.
Sci Rep. 2023 Mar 31;13(1):5320. doi: 10.1038/s41598-023-32455-1.
To quantitatively analyze the number and density of macrophage-like cells (MLCs) at the vitreoretinal interface at macular region in diabetic retinopathy (DR) with and without diabetic macular edema (DME). This cross-sectional study involved 240 eyes of 146 treatment-naïve DR patients, including 151 eyes with DME. The number and density of MLCs were analyzed quantitatively using optical coherence tomography angiography (OCTA) and were compared between DME and non-DME eyes as well as proliferative DR (PDR) and non-PDR (NPDR) eyes. Correlation between MLCs density and vessel density of macular superficial capillary plexus (SCP) at macular region was evaluated. The number and density of macular MLCs were both elevated in DME group compared to non-DME group (all p < 0.001). The morphology of MLCs in DME eyes appeared larger and fuller. NPDR eyes had higher number and density of MLCs (p = 0.027 and 0.026), greater central macular thickness (CMT) (p = 0.002) and vessel density than PDR eyes in non-DME group but comparable to PDR eyes in DME group. The number and density of MLCs at macular region were significantly higher with larger and fuller morphology in DR patients with DME than those without DME. PDR eyes had fewer MLCs than NPDR eyes for DR eyes without DME.
定量分析糖尿病性视网膜病变（DR）伴或不伴糖尿病性黄斑水肿（DME）患者黄斑区视网膜前界面巨噬细胞样细胞（MLC）的数量和密度。本横断面研究纳入了 146 例未经治疗的 DR 患者的 240 只眼，其中 151 只眼合并 DME。使用光相干断层扫描血管造影（OCTA）定量分析 MLC 的数量和密度，并比较 DME 眼与非 DME 眼以及增殖性 DR（PDR）眼与非增殖性 DR（NPDR）眼之间的差异。评估黄斑区浅层毛细血管丛（SCP）血管密度与 MLC 密度之间的相关性。与非 DME 组相比，DME 组的黄斑 MLC 数量和密度均升高（均 p<0.001）。DME 眼 MLC 的形态较大且更饱满。与非 DME 组的 PDR 眼相比，NPDR 眼的 MLC 数量和密度更高（p=0.027 和 0.026），中央黄斑厚度（CMT）更大（p=0.002），非 DME 组的 SCP 血管密度更高，但与 DME 组的 PDR 眼相似。与非 DME 组相比，DME 患者的 MLC 数量和密度更高，形态更大且更饱满。与 NPDR 眼相比，非 DME 组的 PDR 眼 MLC 数量更少。
