除莠霉素A的化学修饰。除莠霉素A的卤代及其他相关衍生物的合成与体内抗肿瘤活性
Chemical modification of herbimycin A. Synthesis and in vivo antitumor activities of halogenated and other related derivatives of herbimycin A.
作者信息
Shibata K, Satsumabayashi S, Sano H, Komiyama K, Nakagawa A, Omura S
出版信息
J Antibiot (Tokyo). 1986 Mar;39(3):415-23. doi: 10.7164/antibiotics.39.415.
PMID:3700243
Abstract
Several halogenated and other related derivatives of herbimycin A have been synthesized and evaluated in vivo for their activities against Ehrlich ascites carcinoma. Some of these derivatives show higher activities than herbimycin A. Among them the derivatives modified at the 4, 5, 6, and 7-positions of the ansa chain showed particularly high activities.
摘要
已经合成了除草霉素A的几种卤代及其他相关衍生物，并在体内评估了它们对艾氏腹水癌的活性。其中一些衍生物显示出比除草霉素A更高的活性。其中，在安莎链的4、5、6和7位修饰的衍生物表现出特别高的活性。
Zotero 插件