Microscale Bioseparations Laboratory and Biomedical Engineering Department, Rochester Institute of Technology, Rochester, New York, USA.
Biological Microsystems Laboratory and Biomedical Engineering Department, Rochester Institute of Technology, Rochester, New York, USA.
Electrophoresis. 2023 Jun;44(11-12):884-909. doi: 10.1002/elps.202200286. Epub 2023 Apr 19.
The selective positioning and arrangement of distinct types of multiscale particles can be used in numerous applications in microfluidics, including integrated circuits, sensors and biochips. Electrokinetic (EK) techniques offer an extensive range of options for label-free manipulation and patterning of colloidal particles by exploiting the intrinsic electrical properties of the target of interest. EK-based techniques have been widely implemented in many recent studies, and various methodologies and microfluidic device designs have been developed to achieve patterning two- and three-dimensional (3D) patterned structures. This review provides an overview of the progress in electropatterning research during the last 5 years in the microfluidics arena. This article discusses the advances in the electropatterning of colloids, droplets, synthetic particles, cells, and gels. Each subsection analyzes the manipulation of the particles of interest via EK techniques such as electrophoresis and dielectrophoresis. The conclusions summarize recent advances and provide an outlook on the future of electropatterning in various fields of application, especially those with 3D arrangements as their end goal.
不同类型的多尺度粒子的选择性定位和排列可用于微流控中的许多应用,包括集成电路、传感器和生物芯片。电泳(EK)技术通过利用目标的固有电特性,为胶体粒子的无标记操纵和图案化提供了广泛的选择。EK 技术已广泛应用于许多最近的研究中,并且已经开发了各种方法和微流控器件设计来实现二维和三维(3D)图案化结构的图案化。本文综述了过去 5 年在微流控领域中电图案化研究的进展。本文讨论了胶体、液滴、合成粒子、细胞和凝胶的电图案化方面的进展。每个小节分析了通过电泳和介电泳等 EK 技术对感兴趣的粒子的操纵。结论总结了最近的进展,并展望了电图案化在各个应用领域的未来,特别是那些以 3D 排列为最终目标的领域。