Additively manufactured MAX- and MXene-composite scaffolds for bone regeneration- recent advances and future perspectives.

Human bones can suffer from various injuries, such as fractures, bone cancer, among others, which has initiated research activities towards bone replacement using advanced bio-materials. However, it is still challenging to design bio-scaffolds with bone-inducing agents to regenerate bone defects. In this regard, MAX-phases and MXenes (early transition metal carbides and/or nitrides) have gained notable attention due to their unique hydrophilicity, bio-compatibility, chemical stability, and photothermal properties. They can be used in bone tissue engineering as a suitable replacement or reinforcement for common bio-materials (polymers, bio-glasses, metals, or hydroxyapatite). To fabricate bio-scaffolds, additive manufacturing is prospective due to the possibility of controlling porosity and creating complex shapes with high resolution. Until now, no comprehensive article summarizing the existing state-of-the-art related to bone scaffolds reinforced by MAX-phases and MXenes fabricated by additive manufacturing has been published. Therefore, our article addresses the reasons for using bone scaffolds and the importance of choosing the most suitable material. We critically discuss the recent developments in bone tissue engineering and regenerative medicine using MAX-phases and MXenes with a particular emphasis on manufacturing, mechanical properties, and bio-compatibility. Finally, we discuss the existing challenges and bottlenecks of bio-scaffolds reinforced by MAX-phases and MXenes before deriving their future potential.