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从药物制剂中测定硫酸特布他林的简易比色法。

Simple colorimetric method for determination of terbutaline sulfate from pharmaceutical preparations.

作者信息

Sane R T, Malkar V B, Nayak V G, Sapre D S

出版信息

J Assoc Off Anal Chem. 1986 Mar-Apr;69(2):186-8.

PMID:3700327
Abstract

A simple colorimetric method is described for the determination of terbutaline sulfate. The method is based on measurement of a colored species formed when terbutaline sulfate is treated with diazotized dapsone and p-nitroaniline at room temperature. Compounds such as starch, talc, and common excipients do not interfere in the reaction. Statistical validation showed that the method was highly precise and accurate. The results agree well with those obtained by other methods reported in the literature.

摘要

描述了一种用于测定硫酸特布他林的简单比色法。该方法基于在室温下将硫酸特布他林用重氮化的氨苯砜和对硝基苯胺处理时形成的有色物质的测量。淀粉、滑石粉和常见辅料等化合物不干扰该反应。统计验证表明该方法具有很高的精密度和准确性。结果与文献中报道的其他方法所获得的结果非常吻合。

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