Research Department - Muriaé Cancer Hospital. Cristiano Varella Foundation. Muriaé, MG, Brazil; Department of Oral Surgery and Pathology, School of Dentistry, Universidade Federal de Minas Gerais, Belo Horizonte, MG, Brazil.
Centro Universitário Faminas, Muriaé, MG, Brazil.
Photodiagnosis Photodyn Ther. 2023 Jun;42:103543. doi: 10.1016/j.pdpdt.2023.103543. Epub 2023 Mar 31.
The aim was to evaluate the effectiveness of photobiomodulation and antimicrobial photodynamic therapy in the treatment of oral mucositis.
Oral Mucositis is a frequent complication of oral cavity and oropharynx cancer. Considering the OM aggravation by microorganisms contamination, disinfection provide by antimicrobial photodynamic therapy could be an effective approach.
This comparative study included fourteen patients undergoing radiochemotherapy for oral cavity and oropharynx cancer treatment, who developed oral mucositis.
photobiomodulation. Intervention group: photobiomodulation and antimicrobial photodynamic therapy. The lesion size, duration, pain, and identification of microorganisms were evaluated.
The mean reduction in oral mucositis size in the intervention group was 0.70 cm² (±0.35) and 0.30 cm² (±1.10) for the control group. The mean duration of oral mucositis was 18.37 days (±12.12) for the intervention group and 23 days (±14.78) for the control group. The intervention group had a mean reduction of 3.40 points on the pain scale (±2.44), while the control group had 0.17 (±2.28). In the intervention group, the predominant isolated microbiota was featured as mixed culture (n = 4/ 50%), followed of Gram Positive (n = 3/ 37.50%), and Gram Negative (n = 1/ 12.55%). In the control group, mixed culture was also more frequent (n = 4 / 66%), followed by Gram Positive (n = 2 /34%). Gram Negative was not predominantly isolated in the control group.
No statistical significance was found between PBM-T alone and PBM-T + PDT. However, the better outcomes reached by PBM-T + PDT group would suggest there could be a role for combined treatment in the management of OM lesions.
评估光生物调节和抗菌光动力疗法治疗口腔黏膜炎的疗效。
口腔黏膜炎是口腔和口咽癌的常见并发症。鉴于微生物污染会加重 OM，抗菌光动力疗法的消毒可能是一种有效的方法。
本研究纳入了 14 名接受口腔和口咽癌放射化疗的患者，这些患者出现了口腔黏膜炎。
光生物调节。干预组：光生物调节和抗菌光动力疗法。评估了病变大小、持续时间、疼痛和微生物鉴定。
干预组口腔黏膜炎面积平均减少 0.70cm²（±0.35），对照组减少 0.30cm²（±1.10）。干预组口腔黏膜炎持续时间为 18.37 天（±12.12），对照组为 23 天（±14.78）。干预组疼痛评分平均降低 3.40 分（±2.44），对照组为 0.17 分（±2.28）。干预组主要分离的微生物群为混合培养（n=4/50%），其次是革兰氏阳性菌（n=3/37.50%）和革兰氏阴性菌（n=1/12.55%）。对照组中混合培养也更为常见（n=4/66%），其次是革兰氏阳性菌（n=2/34%）。对照组中未主要分离出革兰氏阴性菌。
单独使用 PBM-T 与 PBM-T+PDT 之间没有统计学意义。然而，PBM-T+PDT 组获得的更好结果表明，联合治疗可能在 OM 病变的治疗中发挥作用。
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