Clinical Evaluation of Intravascular Blood Irradiation with Laser, Photobiomodulation, and Photodynamic Therapy in Cancer Patients with Mucositis.

To assess the clinical application of intravascular laser irradiation of blood (ILIB), photodynamic therapy (PDT), and photobiomodulation therapy (PBM-T) in mucositis in cancer patients. PBM-T and PDT are used for the management of oral mucositis (OM) and there are no studies associating intravascular laser irradiation of blood (ILIB) for this purpose. Thirty-six patients were allocated by convenience into three groups according to the established therapy: PDT+PBM-T ( = 10); PDT+PBM-T+ILIB ( = 10), and ILIB ( = 16). PDT was performed with the photosensitizer curcumin and irradiation of the oral cavity with blue light-emitting diode (LED) (power 1200 mW and wavelength 468 nm). PBM-T was performed using low-intensity laser (power 100 mW, wavelength 660 nm, and spot energy 1 J) at 26 points of the oral cavity. ILIB was applied with a bracelet on the radial artery using the low-intensity laser (100 mW of power, 660 nm wavelength, and 30 J of total energy). All therapies were performed weekly for 5 weeks. The results of the OM degrees were analyzed using the Wilcoxon test. There was a significant reduction in the degrees of OM after treatment with PDT+PBM-T ( = 0.0117), PDT+PBM-T+ILIB ( = 0.0277), and ILIB ( = 0.0277). It was concluded that ILIB, PDT, and PBM-T reduced the severity of mucositis and prevented its onset. Clinical Trial Registration number: RBR-54XS25.