Cruzeiro Do Sul University, Paulista Avenue, 1415 Centro, São Paulo, São Paulo, 01311-925, Brazil.
Multidisciplinary Health Institute, Federal University of Bahia, Vitória da Conquista, Rio de Contas Street, 58 Candeias, Bahia, 450029-094, Brazil.
Support Care Cancer. 2022 Sep;30(9):7365-7371. doi: 10.1007/s00520-022-07127-x. Epub 2022 May 24.
As conventional treatments currently available for mucositis are not considerably effective, there is a need to implement an adjuvant protocol for the treatment of oral mucositis in patients undergoing radiotherapy and chemotherapy.
To evaluate the effect of photobiomodulation (PBM) and antimicrobial photodynamic therapy (aPDT) mediated by curcumin and blue LED as an adjunct treatment of oral mucositis for oncology patients using chemotherapy and/or radiotherapy.
Clinical, randomized study, in a single location, in an oncology service of a general hospital, with a total of 30 patients (over 18 years old) with stable oral mucosa lesions in the process of chemotherapy and/or radiotherapy. The patients were divided into 3 groups: control group (treated with nystatin), PBM group (treated with low-level laser therapy), and the aPDT group (treated with 450-nm blue LED and curcumin photosensitizer).
The results showed, by means of intra-group comparisons, that the two experimental treatments promoted yeast reduction of the genus Candida in the last two evaluations (21 days and 30 days), but not in the first two evaluations (7 days and 14 days). The intra-group comparisons showed that the control and aPDT group showed a significant difference in the degree of mucositis over the four evaluations performed, with the results pointing out that the mucositis worsened in the control group from the 14th day, while reduced in the aPDT group from the 21st day of treatment.
A reduction in the degree of mucositis and pain score was observed in the PBM and aPDT groups, with the aPDT group standing out when presenting early clinical improvement in relation to the PBM group and the control group, thus emphasizing its effectiveness within the desired aspects. Regarding the antimicrobial effect, aPDT showed a greater reduction of yeasts of the genus Candida in the tested parameters.
由于目前常规治疗口腔黏膜炎的方法效果并不显著，因此有必要为接受放化疗的患者制定一种辅助治疗口腔黏膜炎的方案。
评估光生物调节（PBM）和基于姜黄素和蓝光 LED 的光动力疗法（aPDT）作为癌症患者接受化疗和/或放疗时口腔黏膜炎辅助治疗的效果。
这是一项在综合医院肿瘤科进行的单中心、临床随机研究，共纳入 30 例（18 岁以上）接受化疗和/或放疗且口腔黏膜稳定的患者。患者被分为 3 组：对照组（使用制霉菌素治疗）、PBM 组（使用低水平激光治疗）和 aPDT 组（使用 450nm 蓝光和姜黄素光敏剂治疗）。
通过组内比较，结果显示两种实验性治疗方法均在最后两次评估（第 21 天和第 30 天）中降低了属念珠菌的酵母数量，但在最初两次评估（第 7 天和第 14 天）中没有。组内比较显示，对照组和 aPDT 组在四次评估中均出现了口腔黏膜炎程度的显著差异，结果表明对照组从第 14 天开始，口腔黏膜炎恶化，而 aPDT 组从第 21 天开始减轻。
PBM 和 aPDT 组均观察到口腔黏膜炎程度和疼痛评分的降低，与 PBM 组和对照组相比，aPDT 组在治疗早期即出现临床改善，因此在预期的方面突出了其有效性。关于抗菌效果，aPDT 在测试参数中显示出对属念珠菌的酵母有更大的减少作用。
