Internal medicine residency program, Rochester General Hospital, Rochester, NY 14621, USA.
The Institute of Medicine, Qiqihar Medical University, Qiqihar 161006, China.
Phytomedicine. 2023 Jun;114:154789. doi: 10.1016/j.phymed.2023.154789. Epub 2023 Mar 29.
Due to its unique physical and chemical properties, lead is still used worldwide in several applications, especially in industry. Both environmental and industrial lead exposures remain a public health problem in many developing and rapidly industrializing countries. Plant polyphenols are pleiotropic in their function and have historically made a major contribution to pharmacotherapy.
To summarize available pre-clinical and limited clinical evidence on plant polyphenols as potential antidotes against lead poisoning and discuss toxic mechanisms of lead.
A comprehensive search of peer-reviewed publications was performed from core collections of electronic databases such as PubMed, Web of Science, Google Scholar, and Science Direct. Articles written in English-language from inception until December 2022 were selected.
In this review, we review key toxic mechanisms of lead and its pathological effects on the neurological, reproductive, renal, cardiovascular, hematological, and hepatic systems. We focus on plant polyphenols against lead toxicity and involved mechanisms. Finally, we address scientific gaps and challenges associated with translating these promising preclinical discoveries into effective clinical therapies.
While preclinical evidence suggests that plant polyphenols exhibit bioprotective effects against lead toxicity, scant and equivocal clinical data highlight a need for clinical trials with those polyphenols.
由于其独特的物理和化学性质，铅在世界范围内的许多应用中仍然被使用，特别是在工业中。环境和工业接触铅仍然是许多发展中国家和快速工业化国家的公共卫生问题。植物多酚在功能上具有多效性，在历史上为药物治疗做出了重大贡献。
总结植物多酚作为潜在解毒剂对抗铅中毒的现有临床前和有限临床证据，并讨论铅的毒性机制。
从 PubMed、Web of Science、Google Scholar 和 Science Direct 等电子数据库的核心收藏中全面搜索同行评议的出版物。选择从开始到 2022 年 12 月以英文撰写的文章。
在这篇综述中，我们回顾了铅的关键毒性机制及其对神经系统、生殖系统、肾脏、心血管系统、血液系统和肝脏系统的病理影响。我们重点介绍了植物多酚对铅毒性的作用及其相关机制。最后，我们讨论了将这些有前途的临床前发现转化为有效临床治疗的相关科学空白和挑战。
虽然临床前证据表明植物多酚对铅毒性具有生物保护作用，但临床数据稀缺且存在争议，这突出了需要对这些多酚进行临床试验。
