Wu Xiangjun, Gao Pengli, Zhang Peng, Shang Yaxin, He Bingxi, Zhang Liwen, Jiang Jingying, Hui Hui, Tian Jie
School of Engineering Medicine & School of Biological Science and Medical Engineering, Beihang University, Beijing, China; Key Laboratory of Big Data-Based Precision Medicine (Beihang University), Ministry of Industry and Information Technology, Beijing, China.
CAS Key Laboratory of Molecular Imaging, Institute of Automation, Chinese Academy of Sciences, Beijing, China; Department of Biomedical Engineering, School of Computer and Information Technology, Beijing Jiaotong University, Beijing, China.
Comput Biol Med. 2023 May;158:106809. doi: 10.1016/j.compbiomed.2023.106809. Epub 2023 Mar 28.
Projection magnetic particle imaging (MPI) can significantly improve the temporal resolution of three-dimensional (3D) imaging compared to that using traditional point by point scanning. However, the dense view of projections required for tomographic reconstruction limits the scope of temporal resolution optimization. The solution to this problem in computed tomography (CT) is using limited view projections (sparse view or limited angle) for reconstruction, which can be divided into: completing the limited view sinogram and image post-processing for streaking artifacts caused by insufficient projections. Benefiting from large-scale CT datasets, both categories of deep learning-based methods have achieved tremendous progress; yet, there is a data scarcity limitation in MPI. We propose a cross-domain knowledge transfer learning strategy that can transfer the prior knowledge of the limited view learned by the model in CT to MPI, which can help reduce the network requirements for real MPI data. In addition, the size of the imaging target affects the scale of the streaking artifacts caused by insufficient projections. Therefore, we propose a parallel-cascaded multi-scale attention module that allows the network to adaptively identify streaking artifacts at different scales. The proposed method was evaluated on real phantom and in vivo mouse data, and it significantly outperformed several advanced limited view methods. The streaking artifacts caused by an insufficient number of projections can be overcome using the proposed method.
与传统的逐点扫描相比,投影式磁粒子成像(MPI)能够显著提高三维(3D)成像的时间分辨率。然而,断层重建所需的密集投影视图限制了时间分辨率优化的范围。计算机断层扫描(CT)中解决此问题的方法是使用有限视图投影(稀疏视图或有限角度)进行重建,这可分为:完成有限视图正弦图以及对因投影不足导致的条纹伪影进行图像后处理。受益于大规模CT数据集,这两类基于深度学习的方法都取得了巨大进展;然而,MPI存在数据稀缺的限制。我们提出了一种跨域知识转移学习策略,该策略可以将模型在CT中学习到的有限视图先验知识转移到MPI中,这有助于降低网络对真实MPI数据的需求。此外,成像目标的大小会影响因投影不足导致的条纹伪影的规模。因此,我们提出了一种并行级联多尺度注意力模块,使网络能够自适应地识别不同尺度的条纹伪影。所提出的方法在真实体模和体内小鼠数据上进行了评估,并且显著优于几种先进的有限视图方法。使用所提出的方法可以克服因投影数量不足而导致的条纹伪影。
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