McBride Philip, Henson Joseph, Edwardson Charlotte L, Maylor Benjamin, Dempsey Paddy C, Rowlands Alex V, Davies Melanie J, Khunti Kamlesh, Yates Thomas
Med Sci Sports Exerc. 2023 Sep 1;55(9):1601-1609. doi: 10.1249/MSS.0000000000003180. Epub 2023 Mar 31.
To investigate associations between 4-yr change in step cadence and markers of cardiometabolic health in people with a history of prediabetes and to explore whether these associations are modified by demographic factors.
In this prospective cohort study, adults, with a history of prediabetes, were assessed for markers of cardiometabolic health (body mass index, waist circumference, high-density lipoprotein cholesterol [HDL-C], low-density lipoprotein cholesterol [LDL-C], triglycerides, and glycated hemoglobin A1c [HbA1c]), and free-living stepping activity (activPAL3™) at baseline, 1 yr, and 4 yr. Brisk steps per day were defined as the number of steps accumulated at ≥100 steps per minute and slow steps per day as those accumulated at <100 steps per minute; the mean peak stepping cadence during the most active 10 minutes of the day was also derived. Generalized estimating equations examined associations between 4-yr change in step cadence and change in cardiometabolic risk factors, with interactions by sex and ethnicity.
Seven hundred ninety-four participants were included (age, 59.8 ± 8.9 yr; 48.7% women; 27.1% ethnic minority; total steps per day, 8445 ± 3364; brisk steps per day, 4794 ± 2865; peak 10-min step cadence, 128 ± 10 steps per minute). Beneficial associations were observed between change in brisk steps per day and change in body mass index, waist circumference, HDL-C, and HbA1c. Similar associations were found between peak 10-min step cadence and HDL-C and waist circumference. Interactions by ethnicity revealed change in brisk steps per day and change in peak 10-min step cadence had a stronger association with HbA1c in White Europeans, whereas associations between change in 10-min peak step cadence with measures of adiposity were stronger in South Asians.
Change in the number of daily steps accumulated at a brisk pace was associated with beneficial change in adiposity, HDL-C, and HbA1c; however, potential benefits may be dependent on ethnicity for outcomes related to HbA1c and adiposity.
研究糖尿病前期患者步频4年变化与心血管代谢健康指标之间的关联，并探讨这些关联是否会受到人口统计学因素的影响。
在这项前瞻性队列研究中，对有糖尿病前期病史的成年人在基线、1年和4年时进行心血管代谢健康指标（体重指数、腰围、高密度脂蛋白胆固醇[HDL-C]、低密度脂蛋白胆固醇[LDL-C]、甘油三酯和糖化血红蛋白A1c[HbA1c]）以及自由生活状态下的步行活动（activPAL3™）评估。每天的快走步数定义为每分钟≥100步时累计的步数，慢走步数定义为每分钟<100步时累计的步数；还得出了一天中最活跃的10分钟内的平均峰值步频。采用广义估计方程研究步频4年变化与心血管代谢危险因素变化之间的关联，并分析性别和种族的交互作用。
纳入794名参与者（年龄59.8±8.9岁；48.7%为女性；27.1%为少数民族；每天总步数8445±3364；每天快走步数4794±2865；10分钟峰值步频128±10步/分钟）。观察到每天快走步数的变化与体重指数、腰围、HDL-C和HbA1c的变化之间存在有益关联。在10分钟峰值步频与HDL-C和腰围之间也发现了类似关联。种族交互作用显示，每天快走步数的变化和10分钟峰值步频的变化与欧洲白人的HbA1c有更强的关联，而在南亚人中，10分钟峰值步频变化与肥胖指标之间的关联更强。
快步走积累的每日步数变化与肥胖、HDL-C和HbA1c的有益变化相关；然而，对于与HbA1c和肥胖相关的结果，潜在益处可能取决于种族。
