Department of Pediatrics, Dr. Ram Manohar Lohia Institute of Medical Sciences, Lucknow, Uttar Pradesh, India.
Department of Pathology, Dr. Ram Manohar Lohia Institute of Medical Sciences, Lucknow, Uttar Pradesh, India.
Curr Rheumatol Rev. 2023;19(4):504-507. doi: 10.2174/1573397119666230331083402.
Juvenile dermatomyositis (JDM), a rare multisystemic autoimmune disease of unknown cause, leads to chronic inflammation of both striated and smooth muscles. SARS - Co V2 virus infection in children generally remain asymptomatic. However, in some children it leads to a detailed immunological response named as multisystem inflammatory syndrome in children (MIS-C). Post recovery, occasionally, children are susceptible to other autoimmune disorders.
Our case post MIS-C developed JDM. 8-year-old malnourished child developed proximal myopathy of both upper and lower limbs post recovery from COVID 19. His disease severity increased within a short span of time and he went on to develop contractures and deformity of both upper and lower limbs. He developed an uncommon complication of JDM in form of highgrade non-Hodgkin's lymphoma.
This case highlights the importance of long-term complications of COVID-19 in children which would gradually evolve in the next few years.
幼年型皮肌炎(JDM)是一种罕见的病因不明的多系统自身免疫性疾病,导致横纹肌和平滑肌的慢性炎症。儿童中 SARS-CoV-2 病毒感染通常无症状。然而,在一些儿童中,它会导致一种名为儿童多系统炎症综合征(MIS-C)的详细免疫反应。康复后,儿童偶尔会易患其他自身免疫性疾病。
我们的病例在 MIS-C 后发展为 JDM。一名营养不良的 8 岁儿童在 COVID-19 康复后出现四肢近端肌无力。他的病情在短时间内迅速恶化,随后出现四肢挛缩和畸形。他患上了 JDM 的一种罕见并发症,表现为高级别非霍奇金淋巴瘤。
本病例强调了 COVID-19 在儿童中的长期并发症的重要性,这些并发症将在未来几年逐渐显现。