鸟嘌呤是嗜肺军团菌属的一种生长因子。
Guanine is a growth factor for Legionella species.
作者信息
Pine L, Franzus M J, Malcolm G B
出版信息
J Clin Microbiol. 1986 Jan;23(1):163-9. doi: 10.1128/jcm.23.1.163-169.1986.
Abstract
Evaluation of previously described chemically defined media for the growth of Legionella pneumophila showed that these media supported poor growth of several strains of L. pneumophila and did not support growth of certain of the Legionella species described later. Growth was stimulated by the dialysate from yeast extract but not by the nondialyzable fraction. Further investigations indicated that the active factors from the yeast extract dialysate were purine or pyrimidine derivatives, and certain known purines and pyrimidines were found to stimulate growth. Of these, guanine universally stimulated growth of all Legionella strains and was a growth requirement for several of the species tested. A balanced, N-(2-acetamido)-2-aminoethanesulfonic acid-buffered, chemically defined medium having guanine or a purine-pyrimidine mix is presented for the general growth of Legionella species.
摘要
对先前描述的用于嗜肺军团菌生长的化学成分确定的培养基进行评估表明，这些培养基支持几种嗜肺军团菌菌株的生长较差，并且不支持后来描述的某些军团菌物种的生长。酵母提取物的透析液可刺激生长，但不可透析部分则不能。进一步的研究表明，酵母提取物透析液中的活性因子是嘌呤或嘧啶衍生物，并且发现某些已知的嘌呤和嘧啶可刺激生长。其中，鸟嘌呤普遍刺激所有军团菌菌株的生长，并且是所测试的几种物种的生长必需物质。本文提出了一种平衡的、以N-(2-乙酰氨基)-2-氨基乙烷磺酸缓冲的、化学成分确定的培养基，该培养基含有鸟嘌呤或嘌呤-嘧啶混合物，用于军团菌物种的一般生长。
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J Clin Microbiol. 1986 Jan;23(1):163-9. doi: 10.1128/jcm.23.1.163-169.1986.
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