Jiang Lin, Tang Ao, Song Lihua, Tong Yigang, Fan Huahao
College of Life Science and Technology, Beijing University of Chemical Technology, Beijing, China.
Front Immunol. 2023 Mar 17;14:1041149. doi: 10.3389/fimmu.2023.1041149. eCollection 2023.
Rotavirus (RV) causes 200,000 deaths per year and imposes a serious burden to public health and livestock farming worldwide. Currently, rehydration (oral and intravenous) remains the main strategy for the treatment of rotavirus gastroenteritis (RVGE), and no specific drugs are available. This review discusses the viral replication cycle in detail and outlines possible therapeutic approaches including immunotherapy, probiotic-assisted therapy, anti-enteric secretory drugs, Chinese medicine, and natural compounds. We present the latest advances in the field of rotavirus antivirals and highlights the potential use of Chinese medicine and natural compounds as therapeutic agents. This review provides an important reference for rotavirus prevention and treatment.
轮状病毒（RV）每年导致20万人死亡，给全球公共卫生和畜牧业带来沉重负担。目前，补液（口服和静脉注射）仍然是治疗轮状病毒胃肠炎（RVGE）的主要策略，且尚无特效药物。本综述详细讨论了病毒复制周期，并概述了可能的治疗方法，包括免疫疗法、益生菌辅助疗法、抗肠道分泌药物、中药和天然化合物。我们介绍了轮状病毒抗病毒药物领域的最新进展，并强调了中药和天然化合物作为治疗剂的潜在用途。本综述为轮状病毒的预防和治疗提供了重要参考。
