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一例对氟康唑单药治疗有反应的新生儿迟发性败血症:病例报告

LATE ONSET SEPTICAEMIA IN A NEONATE WHICH RESPONDED TO FLUCONAZOLE MONOTHERAPY: A CASE REPORT.

作者信息

Adigun M B, Akindolire A E, Adedeji W A

机构信息

Department of Paediatrics, University College Hospital, Ibadan.

Department of Clinical Pharmacology, University College Hospital, Ibadan.

出版信息

Ann Ib Postgrad Med. 2022 Jun;20(1):49-52.

Abstract

Systemic candida infections in the neonatal population are commonly seen especially in low birth weight, preterm neonates admitted to the Neonatal Intensive Care Unit. Albicans spp is the most commonly isolated but in more recent times, fluconazole resistant spp such as have been reported to cause healthcare associated infections. This is a case of a 12-day old, term, low birth weight (2.45 kg), male neonate delivered to a 32-year-old through elective caesarian section (CS) at term. He was well till the 12th day of life when he developed respiratory distress and sub-optimal oxygen saturation requiring supplemental oxygen. Chest x-ray showed prominent vascular markings with no active focal lung lesion and he was managed for suspected Aspiration Pneumonitis until a blood culture on the 10th day of admission yielded . He had a monotherapy of intravenous fluconazole, made progressive clinical improvement and was discharged on oral fluconazole to complete a 6 weeks course on outpatient basis.

摘要

新生儿全身性念珠菌感染很常见,尤其是在入住新生儿重症监护病房的低体重早产儿中。白色念珠菌是最常分离出的菌种,但近年来,已有报道称耐氟康唑的菌种如[此处原文缺失具体菌种]会引起医疗相关感染。这是一例12日龄、足月儿、低体重(2.45千克)的男性新生儿,其母亲32岁,足月时通过择期剖宫产分娩。出生后直至第12天情况良好,之后出现呼吸窘迫和氧饱和度欠佳,需要补充氧气。胸部X光显示血管纹理增粗,无活动性局灶性肺部病变,最初按疑似吸入性肺炎进行治疗,直到入院第10天血培养分离出[此处原文缺失具体结果]。给予静脉注射氟康唑单药治疗,临床症状逐渐改善,出院时口服氟康唑以完成6周的门诊疗程。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5cd8/10061664/135152f9f5be/AIPM-20-49_F1.jpg

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