Gorenflo Maria P, Shen Alan, Murphy Erin S, Cullen Jennifer, Yu Jennifer S
Cleveland Clinic Lerner College of Medicine, Case Western Reserve University, Cleveland, OH, United States.
Department of Radiation Oncology, Cleveland Clinic Foundation, Cleveland, OH, United States.
Front Oncol. 2023 Mar 17;13:1110473. doi: 10.3389/fonc.2023.1110473. eCollection 2023.
In the United States, an individual's access to resources, insurance status, and wealth are critical social determinants that affect both the risk and outcomes of many diseases. One disease for which the correlation with socioeconomic status (SES) is less well-characterized is glioblastoma (GBM), a devastating brain malignancy. The aim of this study was to review the current literature characterizing the relationship between area-level SES and both GBM incidence and prognosis in the United States. A query of multiple databases was performed to identify the existing data on SES and GBM incidence or prognosis. Papers were filtered by relevant terms and topics. A narrative review was then constructed to summarize the current body of knowledge on this topic. We obtained a total of three papers that analyze SES and GBM incidence, which all report a positive correlation between area-level SES and GBM incidence. In addition, we found 14 papers that focus on SES and GBM prognosis, either overall survival or GBM-specific survival. Those studies that analyze data from greater than 1,530 patients report a positive correlation between area-level SES and individual prognosis, while those with smaller study populations report no significant relationship. Our report underlines the strong association between SES and GBM incidence and highlights the need for large study populations to assess SES and GBM prognosis to ideally guide interventions that improve outcomes. Further studies are needed to determine underlying socio-economic stresses on GBM risk and outcomes to identify opportunities for intervention.
在美国，个人获取资源的机会、保险状况和财富是影响多种疾病风险和预后的关键社会决定因素。胶质母细胞瘤（GBM）是一种毁灭性的脑恶性肿瘤，与社会经济地位（SES）的相关性尚未得到充分描述。本研究的目的是回顾当前关于美国地区层面SES与GBM发病率及预后之间关系的文献。通过查询多个数据库来识别关于SES与GBM发病率或预后的现有数据。论文根据相关术语和主题进行筛选。然后构建了一篇叙述性综述来总结该主题的现有知识体系。我们共获得三篇分析SES与GBM发病率的论文，所有论文均报告地区层面SES与GBM发病率呈正相关。此外，我们发现14篇关注SES与GBM预后的论文，涉及总生存期或GBM特异性生存期。那些分析超过1530例患者数据的研究报告地区层面SES与个体预后呈正相关，而研究人群较小的研究则报告无显著关系。我们的报告强调了SES与GBM发病率之间的紧密关联，并强调需要有大量研究人群来评估SES与GBM预后，以便理想地指导改善预后的干预措施。需要进一步研究以确定GBM风险和预后背后的社会经济压力，从而识别干预机会。
