Wang Min, Fu Lulu, Xu Ying, Ma Shuai, Zhang Xueying, Zheng Lianwen
Reproductive Medical Center, Department of Obstetrics and Gynecology, The Second Hospital of Jilin University, Changchun, China.
Front Oncol. 2023 Mar 17;13:1138142. doi: 10.3389/fonc.2023.1138142. eCollection 2023.
Ovarian, endometrial, and cervical cancer are common gynecologic malignancies, and their incidence is increasing year after year, with a younger patient population at risk. An exosome is a tiny "teacup-like" blister that can be secreted by most cells, is highly concentrated and easily enriched in body fluids, and contains a large number of lncRNAs carrying some biological and genetic information that can be stable for a long time and is not affected by ribonuclease catalytic activity. As a cell communication tool, exosome lncRNA has the advantages of high efficiency and high targeting. Changes in serum exosome lncRNA expression in cancer patients can accurately reflect the malignant biological behavior of cancer cells. Exosome lncRNA has been shown in studies to have broad application prospects in cancer diagnosis, monitoring cancer recurrence or progression, cancer treatment, and prognosis. The purpose of this paper is to provide a reference for clinical research on the pathogenesis, diagnosis, and treatment of gynecologic malignant tumors by reviewing the role of exosome lncRNA in gynecologic cancers and related molecular mechanisms.
卵巢癌、子宫内膜癌和宫颈癌是常见的妇科恶性肿瘤，其发病率逐年上升，高危患者群体呈年轻化趋势。外泌体是一种微小的“茶杯状”囊泡，可由大多数细胞分泌，在体液中高度浓缩且易于富集，包含大量携带某些生物和遗传信息的长链非编码RNA（lncRNA），这些信息可长期稳定存在，且不受核糖核酸酶催化活性的影响。作为一种细胞通讯工具，外泌体lncRNA具有高效性和高靶向性的优点。癌症患者血清外泌体lncRNA表达的变化能够准确反映癌细胞的恶性生物学行为。研究表明，外泌体lncRNA在癌症诊断、监测癌症复发或进展、癌症治疗及预后方面具有广阔的应用前景。本文旨在通过综述外泌体lncRNA在妇科癌症中的作用及相关分子机制，为妇科恶性肿瘤的发病机制、诊断和治疗的临床研究提供参考。
